Tkachenko P. I., Lokes K. P., Bondarenko V. V., Bilokon S. O., Ivanytska O. S., Rezvina K. Y., Ivanicky I. O.

CLINICAL CHARACTERISTIC OF DIFFERENT TYPES OF CONSERVATIVE TREATMENT OS PATHOLOGICAL SCARS OF HEAD AND NECK


About the author:

Tkachenko P. I., Lokes K. P., Bondarenko V. V., Bilokon S. O., Ivanytska O. S., Rezvina K. Y., Ivanicky I. O.

Heading:

DENTISTRY

Type of article:

Scentific article

Annotation:

40 patients of the Department of Maxillofacial Surgery of the Poltava Regional Clinical Hospital with pathological scars of maxillofacial localization. Patients were divided into two clinical groups of 20 people each. Patients of the first group underwent ultraphonophoresis of Contractubex for 15 days. For patients of the second group – lidase electrophoresis. The nature of the scars was evaluated according to four clinical signs (type, consistency, color and sensitivity), expressed on a 4-point scale. The objective clinical symptoms in case of different types of treatment mainly had no statistically significant changes (except P3 in the first clinical group). When analyzing the color of cictrical tissues, a statistically significant decrease in the P3 index by 50% was noted in patients who underwent a course of therapy using Contractubex ultraphonophoresis. The second clinical group was characterized by a decrease in this indicator, which was not statistically significant. The subjective clinical indicator (scar sensitivity) experienced statistically significant changes in both clinical groups. Namely, a statistically significant decrease of P4 index on 58.3% after treatment in the first clinical group and 50.0% in the second clinical group, respectively. There were no heartburn complaints in both clinical groups after the different types of conservative treatment. The total scores experienced a statistically significant decrease in both clinical groups. During the 15-days course of therapy with Contractubex ultraphonophoresis, a statistically significant decrease in the total indicator by 36.8% was noted. And in the second clinical group (in case of using Lidasa electrophoresis) it was decrease on 20.6%, respectively. Obtained data describes the positive effect of such methods of conservative treatment of cicatrical tissues. But such level of positive changes of clinical characteristics has light result and can be used for the combine treatment of such pathological conditions of skin. Thus, the investigated methods of conservative treatment mainly affect the subjective characteristics of scar tissue. Moreover, the use of contractubex ultraphonophoresis has a more pronounced effect than the use of lidase electrophoresis.

Tags:

pathological scars,treatment of scars,maxillofacial area,clinical symptoms

Bibliography:

  1. Loza KhO, Stavytskyi SO, Loza EO, Voloshina LI, Avetikov DS. Clinical characteristic of postoperative state of cicatricially-changed cutaneous tissues. Klin Khir. 2016 Apr;(4):61-3.
  2. Ogawa R. The Most Current Algorithms for the Treatment and Prevention of Hypertrophic Scars and Keloids: A 2020 Update of the Algorithms Published 10 Years Ago. Plast Reconstr Surg. 2022 Jan 1;149(1):79e-94e. DOI: 10.1097/PRS.0000000000008667.
  3. Lokes KP, Avetikov DS, Klitynska OV, Brekhlichuk PP, Bun YI. The histotopographic features of formation of keloid scars of maxillofacial localization. Wiad Lek. 2020;73(3):565-568.
  4. Leavitt T, Hu MS, Marshall CD, Barnes LA, Lorenz HP, Longaker MT. Scarless wound healing: finding the right cells and signals. Cell and Tissue Research. 2016;365:483-93.
  5. Lee HJ, Jang YJ. Recent Understandings of Biology, Prophylaxis and Treatment Strategies for Hypertrophic Scars and Keloids. Int J Mol Sci. 2018 Mar 2;19(3):711. DOI: 10.3390/ijms19030711. 
  6. Nilforoushzadeh MA, Heidari-Kharaji M, Alavi S, Nouri M, Zare S, Mahmoudbeyk M, et al. Acne scar treatment using combination therapy: Subcision and human autologous fibroblast injection. J Cosmet Dermatol. 2022 Oct;21(10):4677-4683. DOI: 10.1111/jocd.14988.
  7. Lee Peng G, Kerolus JL. Management of Surgical Scars. Facial Plast Surg Clin North Am. 2019 Nov;27(4):513-517. DOI: 10.1016/j. fsc.2019.07.013.
  8. Voloshyna LI, Toropov OA, Boyko IV, Yatsenko PI, Steblovskyi DV, Bukhanchenko OP, et al. Comparative characteristics of clinical indicators of the condition of scar tissue of the facial skin at different stages of the postoperative period depending on the chronotype of the person. Wiad Lek. 2022;75(6):1569-1572. DOI: 10.36740/WLek202206126.
  9. Marimuthu Somasundaram S, Subbaraya U, Durairajan SG, Rajendran S, Gopalakrishnan J, Shahul Hameed B, et al. Comparison of two different electrophoretic methods in studying the genetic diversity among plantains (Musa spp.) using ISSR markers. Electrophoresis. 2019 May;40(9):1265-1272. DOI: 10.1002/elps.201800456.

Publication of the article:

«Bulletin of problems biology and medicine» Issue 1 (168), 2023 year, 418-421 pages, index UDK 617.51/.53-003.92-085

DOI: