PECULIARITIES OF THE USE OF DRUGS WITH ANTIOXIDANT AND IMMUNOSTIMULATING ACTION IN THE COMPLEX TREATMENT OF PATIENTS WITH ODONTOGENIC PHLEGMONS

Varzhapetian S. D., Grigorov S. O., Malanchuk V. O.

DENTISTRY

Scentific article

Currently, the problem of conservative treatment of patients with odontogenic phlegmons is not only a medical, but also a medical and social problem, despite the large number of studies in this field of maxillofacial surgery. A special place is occupied by studies conducted with the aim of establishing the specifics of the use of drugs that have antioxidant and immunostimulating effects as part of the conservative therapy of phlegmon. Today, there are many works of both domestic and foreign scientists, which contain information on the use of antioxidants and immunostimulants as monotherapy, and data on their combined use are isolated and contradictory. The aim of this work was to increase the effectiveness of conservative treatment of patients with odontogenic phlegmons by including phosphatidylcholine nanocapsules in complex therapy. 60 patients participated in the study, who were divided into two groups of 30 people each: in the 1st group, the treatment was carried out according to the standard protocol, in the 2nd – according to the protocol with an addition: the conservative therapy included intravenous injections of the effectiveness of the conservative treatment of patients with odontogenic phlegmons by including phosphatidylcholine nanocapsules in complex therapy. Clinical and laboratory research methods were used during the work. It was established that in group 2, the main indicators visualizing the dynamics of purulent wound healing decrease already on the 5-7th day of the postoperative period, with the appearance of granulations already on the 6.8±0.3 day. We recorded a complete cleansing of the wound in 9.9±0.5 days, and the average length of stay of the patient in the hospital was 10.2±0.6 days. It has been proven that the use of phosphatidylcholine nanocapsules in the complex treatment of patients of the 2nd group leads to a significant decrease in the number of rod-shaped neutrophils (2.5±0.1%) and an increase in the content of lymphocytes (24.3±0.4%). It should also be noted that in patients of the second group, on the eighth day of the postoperative period, the content of T- and B-lymphocytes is recorded as the closest to the norm, namely 41.2±0.5% and 56.7±0.5%, respectively, which leads to optimize the work of the immune system and is proof of the effectiveness of using the author’s method of treatment. The obtained results formed a clinical and laboratory evidence base for the effectiveness of conservative treatment of patients with odontogenic phlegmons by including phosphatidylcholine nanocapsules in complex therapy as part of complex therapy in patients with odontogenic phlegmons.

odontogenic phlegmon,complex treatment,conservative treatment,purulent wound regeneration,antioxidants and immunostimulators

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«Bulletin of problems biology and medicine» Issue 1 (168), 2023 year, 396-399 pages, index UDK 617.52-002.3-085:612.015.6

10.29254/2077-4214-2023-1-168-396-399