SEARCH OF NEW BIOANTAGONISTS OF EMBRYOTOXICITY OF CADMIUM CHLORIDE IN A CHRONIC EXPERIMENT ON RATS

Shatorna V. F., Kononova I. I., Garets V. I., Nefodova O. O., Lomyha L. L

BIOLOGY

Scentific article

Aspects of the chronic effect of cadmium salts on the course of embryogenesis, both as an isolated effect and with microelements that have bioantagonistic properties in relation to the toxicity of heavy metals, are poorly studied. Thus, the actual direction of morphological experimental studies is the search for new possible bioantagonists of cadmium toxicity among trace elements that can affect dyselementoses, maintaining body homeostasis, including during pregnancy. The purpose of the experiment was to determine the degree of embryotoxicity of cadmium chloride at a dose of 2.0 mg/kg with isolated intragastric administration and to search for possible bioantagonists among zinc and copper succinates when combined with cadmium chloride in a chronic experiment. The study was carried out on 32 pregnant female Wistar rats, which were divided into 4 experimental groups: the first – control; the second – isolated administration of a solution of cadmium chloride at a dose of 2.0 mg/kg; the third – combined administration of a solution of cadmium chloride at a dose of 2.0 mg/kg + zinc succinate at a dose of 5 mg/kg; the fourth – combined administration of a solution of cadmium chloride at a dose of 2.0 mg/kg + copper succinate 0.1 mg/kg. The possible negative effect of the studied substances on embryonic development was determined by the ability to increase the level of all types of embryonic mortality. The analysis of the obtained results showed that the isolated chronic administration of cadmium chloride at a dose of 2.0 mg/ kg has a pronounced embryotoxic effect on the number of embryos, total embryonic mortality, pre-implantation and post-implantation embryonic mortality in rats. The combined administration of zinc or copper succinates with cadmium chloride has a modifying effect on the embryotoxicity of cadmium chloride in terms of the main indicators of embryotoxicity, and the succinates themselves can be considered as potential bioantagonists of cadmium during chronic exposure in the experiment.

rats,embryotoxicity,cadmium,zinc,copper

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«Bulletin of problems biology and medicine» Issue 1 (168), 2023 year, 92-96 pages, index UDK 616.61:591.3:546.48:612.6

10.29254/2077-4214-2023-1-168-92-96