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    Bulletin of problems biology and medicine / Issue 1 (168), 2023 / VASCULAR DEPRESSION AND CARDIOVASCULAR COMPLICATIONS OF TYPE 2 DIABETES

    Kostrikova U. A., Myakinkova L. O., Pustovoit G. L., Yarmola T. I.

    VASCULAR DEPRESSION AND CARDIOVASCULAR COMPLICATIONS OF TYPE 2 DIABETES

    About the author:

    Kostrikova U. A., Myakinkova L. O., Pustovoit G. L., Yarmola T. I.

    Heading:

    LITERATURE REVIEWS

    Type of article:

    Scentific article

    Annotation:

    In recent years, the prevalence of depression in the world has increased significantly. Depression is an independent risk factor for the development of cardiovascular, cerebrovascular, and neurodegenerative diseases. Depression is widespread in vascular pathology of the brain, diabetes and coronary heart disease. The aim of the work was to generalize existing scientific data, which highlight the impact of depression on the course of type 2 diabetes, coronary heart disease and vascular endothelial dysfunction. Analysis of the bidirectional relationship between depression and macrovascular and microvascular complications of diabetes found that depression increases the risk of myocardial infarction, coronary heart disease, and congestive heart failure associated with type 2 diabetes. A distinctive feature of vascular depression determined by magnetic resonance imaging is the presence of lesions of the white matter of the brain, identified as its hyperintensity. White matter hyperintensities are particularly associated with cerebrovascular risk factors, including diabetes, heart disease, and hypertension, and are associated with cognitive impairment and depression. The development of white matter hyperintensity is facilitated by vascular dysregulation, transient ischemia, ischemic damage, and pathological processes that are accompanied by arterial hypertension. In depressive disorders, a violation of the regulation of vascular tone is expressed. Decreased cerebral blood flow can lead to impairment of its regional functions, contributing to affective and cognitive symptoms. Vascular intima growth, increased arterial stiffness, and endothelial dysfunction are changes expressed in depression. Vascular pathology leads to a decrease in the volumetric velocity of blood flow and vasomotor reactivity. Vasoactive agents released from the parenchyma of the brain can affect cells located in the vascular system, causing an appropriate vascular response. The regulatory mechanisms of the influence of glucose, nitric oxide, pro-inflammatory cytokines, arachidonic acid, eicosanoids on vascular regulation and their disturbances in patients with depression and type 2 diabetes are described. Features of astrocytic and neuronal homeostasis of the brain, neurotoxicity of disorders of carbohydrate metabolism and glutamate metabolism, their importance in the development of depression, violation of vasoactive reactions in patients with type 2 diabetes and cardiovascular risk.

    Tags:

    depression,diabetes,vascular endothelial regulation,cardiovascular diseases,vasoactive substances.

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    Publication of the article:

    «Bulletin of problems biology and medicine» Issue 1 (168), 2023 year, 17-29 pages, index UDK 616.379-008.64

    DOI:

    10.29254/2077-4214-2023-1-168-17-29