THE EFFECT OF NONSTEROIDAL ANTI-INFLAMMATORY DRUGS ON THE CONDITION OF THE MUCOUS MEMBRANE OF THE ESOPHAGOGASTRODUODENAL ZONE

Ratchyk V. M., Turitska T. G., Oliinyckov H. V.

CLINICAL AND EXPERIMENTAL MEDICINE

Scentific article

82 patients with pathology of the esophagogastroduodenal zone (EGDZ) caused by the action of nonsteroidal anti-inflammatory drugs (NSAIDs) were examined. The average age was 48.27±2.3 years with a predominance of men (63.4%). Depending on the duration of taking NSAIDs, patients are divided into two groups: Group I – 42 patients (< 4 weeks) and Group II – 40 patients (> 3 months). The “Minimum Standard Terminology in Endoscopy of the Digestive System” was used to standardize the results of endoscopic examination. The following were determined in the gastric contents: pH, concentration of pepsin, glycoproteins. The aim of the study was to evaluate the qualitative changes of gastric juice and the condition of the mucous membrane (MM) of the esophagogastroduodenal zone in patients depending on the duration of action of NSAIDs. It was established that in 68 (82.9%) patients of both groups induced by the action of NSAIDs, hyperacidic and acid secretion prevailed. The maximum increase in acid production was observed in patients of the II group. It was established that the maximum increase in enzymatic activity was observed in patients of the II group, in whom the activity of pepsin increased by 2.3 times compared to the control (p<0.05). The concentration of glycoproteins in gastric juice significantly (p<0.05) decreased in 53 (64.6%) of the studied patients. At the same time, if the decrease in the I group by 1.25 times compared to the control was noted in 52.4% of patients, then in the II group with a significant duration of NSAIDs use, it gradually decreased to (0.04±0.001) mg/ml in 2.5 times in 77.5% of patients. When examining the macroscopic features of the state of MM EGDZ in patients with the effect of NSAIDs, the prevalence of pathological changes in the antral part of the stomach was established, where more pronounced inflammation was noted in the II group of patients with a longer duration of action of the drugs. Thus, the imbalance of aggressive and protective mechanisms of gastric juice in the direction of aggression and the macroscopic picture of MM of the upper gastrointestinal tract changed under the influence of NSAIDs and depended on the duration of action of the drugs.

NSAIDs,acid production,pepsin,glycoproteins,endoscopy,gastroduodenopathy

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«Bulletin of problems biology and medicine» Issue 1 (168), 2023 year, 212-218 pages, index UDK 616.33:[008.839:072.1]:616-035.2

10.29254/2077-4214-2023-1-168-212-218