CHANGES IN THE MAIN INDICATORS OF EMBRYO LETHALITY IN RATS UNDER THE INFLUENCE OF CADMIUM SALTS

Kolosova I. I.

BIOLOGY

Scentific article

The population of a modern metropolis has an accumulation of various chemical, including toxic, elements in their bodies, including cadmium. Cadmium enters the human body through the gastrointestinal tract with food and drinking water and the respiratory tract, and a significant amount of cadmium is absorbed from cigarette smoke. Accumulating in the body, cadmium has a negative impact on health, affecting the kidneys, liver, circulatory and reproductive systems, and can lead to the formation of diseases during the intrauterine period. The aim of our study was to experimentally determine the potential embryotoxic effects of cadmium chloride and cadmium citrate (at a dose of 1.0 mg/kg) in isolation and under conditions of correction with citrates (cerium, zinc and a nanocomposite based on iodine, sulfur and selenium citrates) when administered intragastrically from the 1st to the 20th day of embryonic development. For the study, 180 young female Wistar rats were used, which were divided into 9 groups, depending on the solutions of cadmium salts or saline. Standard indicators of embryonic development, namely: the average number of fetuses, total embryonic mortality, preimplantation mortality and postimplantation mortality on the 13th and 20th day of embryogenesis indicate a pronounced embryonic lethal effect of cadmium salts, manifested by an increase in total embryonic mortality due to an increase in preimplantation and postimplantation mortality of rat embryos compared to the control group at both studied periods of embryogenesis and an embryotoxic effect manifested by a decrease in the number of live fetuses per female. In the groups of combined action of cadmium salts with cerium/zinc citrates/nanocomposite (iodine + sulfur + selenium), the use of citrates led to an improvement in the studied indicators (reduction in the number of fetuses and their weight, intrauterine survival rate, an increase in total, preimplantation and postimplantation embryonic mortality) compared to the groups of cadmium salts, which indicates a decrease in the negative effect of cadmium on embryonic mortality in rats.

embryogenesis,embryonic mortality,cadmium chloride,cadmium citrate,experiment

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«Bulletin of problems biology and medicine» Issue 1 (168), 2023 year, 80-85 pages, index UDK 612.3:591.39:661.852:661.782-092.9

10.29254/2077-4214-2023-1-168-80-85