CHANGES IN THE BIOCHEMICAL INDICATORS OF MANDIBULA BONE TISSUE AFTER REMOVAL OF MOLARS AND AUGMENTATION OF THE ALVEOLAR PROCESS

Kolesnichenko M. O., Savchenko D. V., Savchenko V. V., Ivanyuk O. S., Zhivotovskyi I. V., Lokes K. P.

DENTISTRY

Scentific article

Atrophy of the alveolar process after tooth extraction can be a contraindication for the placement of dental implants or worsen the aesthetic result of the placed implant or reconstructive prosthetics. Approximately 40% of alveolar height and 60% of alveolar width are susceptible to alveolar bone resorption within 6 months after tooth extraction. According to literature data, 29-63% of horizontal and 11-22% of vertical bone loss occurs during the first 6 months after tooth extraction without the use of alveolar bud preservation techniques. The following biochemical indicators of non-collagenous proteins were investigated: the content of proteoglycans (hexuronic acids and chondroitin-4 and chondroitin-6-sulfates) and carbohydrate derivatives of glycoproteins (N-acetylneuraminic acid and fucose, not bound to proteins) in the mandibular bone tissue. The material for the study was obtained during the tooth extraction and three months later simultaneously with the surgical stage of dental implantation in all three groups. At the time of the surgical stage of dental implantation in patients of the first group, whose bone defect after molar removal was augmented with «Cerabone» granules, a decrease in the content of hexuronic acids by 5.4% compared to the first day of the study was established. For the second group, a probable decrease of this indicator by 3.7% was noted, for the control group, a probable decrease in the content of hexuronic acids was noted by 11.9%. A probable decrease in the content of chondroitin sulfates by 8.7%, 13.4% and 15.4% was noted, respectively, for the first, second and control groups. The level of fucose not bound to proteins was significantly increased by 5.1% only in the control group. A probable decrease in the content of N-acetylneuramine was noted in all three groups relative to the first period of observation by 8.6%, 3.5% and 19.6%, respectively. According to the research data, it was found that the content of hexuronic acids and N acetylneuraminic acid underwent the most significant changes, while the indicators of fucose, not bound to proteins and chondroitin sulfates were characterized by more stable values for the studied period. The use of «Cerabone» granules both as a monopreparation and in combination with a keratoxenoimplant for augmentation of the bone defect of the alveolar process contributed to a less pronounced decrease in the level of proteoglycans and glycoproteins compared to the control.

augmentation of the alveolar process,proteoglycans,glycoproteins,bone tissue

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«Bulletin of problems biology and medicine» Issue 1 (168), 2023 year, 412-417 pages, index UDK 616.716.4-018.4-074-026.19-02:[616.314.7-089.87+616.716.87-089.844]]

10.29254/2077-4214-2023-1-168-412-417