COMPARATIVE ANALYSIS OF THE PONS MORPHOMETRIC PARAMETERS ACCORDING TO THE DATA OF MRI IMAGES

Boіagina O. D., Popadynets O. H., Kolomiichenko Yu. A., Lytvynenko N. V.

MORPHOLOGY

Scentific article

Modern methods of magnetic resonance imaging make it possible to directly examine the brainstem structure and make it possible to determine the location of the main internal structures, which can be very impor-tant in the interpretation of MRI images. The study’s primary goal is to determine the pattern of differences in age transformation and gender dimorphism of the pons morphometric parameters. The work used 150 MRI images of the brain in two mutually perpendicular projections (sagittal and frontal) of men and women aged 4 to 35. Morphometric analysis was carried out using the RadiAnt Dicom Viewer software on MR-tomograms performed in the sagittal plane in T1 and T2 weighted image modes. After obtaining the results and comparing the arithmetic mean of the pons longitudinal dimensions of boys and girls in the period of the first childhood, it is possible to make sure that there are no reliable signs of gender dimorphism in this age group. Furthermore, the value results of the pons longitudinal dimensions of boys and girls in the period of second childhood, as in the previous age group, are also not significantly different from similar indicators. When considering the pons morphometric indicators of adolescent boys and girls, the distribution range of individual indicators of the pons longitudinal dimensions is within wider limits. Still, it is also not possible to talk about reliable signs of gender dimorphism. Regarding the pons height of boys and girls in young adulthood, as in the previous age groups, we do not have reliable data on the difference in the pons longitudinal dimensions of boys and girls. When considering the pons longitudinal dimensions of men and women of the first period of mature age, which is regarded as the most stable in ontogenesis, but despite the extensive distribution range of morphometric indicators of the pons longitudinal dimensions within the groups, it is not possible to assert the presence of gender dimorphism. Therefore, it was established that the indicators of the pons longitudinal dimensions of men do not reliably differ from the similar indicators of the pons longitudinal dimensions of women, which indicates the absence of gender dimorphism, also during the research, an extensive distribution range of morphometric indicators of the pons longitudinal dimensions within age groups was revealed.

nervous system,brain,hindbrain,structure,age-related changes,sexual characteristics,anatomy,morphometric analysis.

1. Hatta T, Satow F, Hatta J, Hashimoto R, Udagawa J, Matsumoto A, Otani H. Development of the pons in human fetuses. Congenit Anom (Kyoto). 2007;47:63-67. 
2. Kyriakopoulou V, Vatansever D, Davidson A, Patkee P, Elkommos S, Chew A, et al. Normative biometry of the fetal brain using magnetic resonance imaging. Brain Struct Funct. 2017;222:2295-307. DOI: 10.1007/s00429-016-1342-6.
3. Elhussein N, Alkhathami HAA, Ayad CE. Norms for Brain Stem: A morphometric MRI Based Study. IOSR J Dent Med Scien. 2017;16:74-9.
4. Polat SÖ, Öksüzler FY, Öksüzler M, Yücel AH. The morphometric measurement of the brain stem in Turkish healthy subjects according to age and sex. Folia Morphol. (Warsz). 2020;79(1):36-45.
5. Massey LA, Jäger HR, Paviour DC, O’Sullivan SS, Ling H, Williams DR, et al. The midbrain to pons ratio. American Academy of Neurology. 2013;80:1856-61.
6. Haratz KK, Lerman-Sagie T. Prenatal diagnosis of brainstem anomalies. Eur J Paediatr Neurol. 2018;22:1016-1026. 
7. Saleem SN. Fetal magnetic resonance imaging (MRI): a tool for a better understanding of normal and abnormal brain development. J Child Neurol. 2013;28:890-908. DOI: 10.1177/0883073813486296.

«Bulletin of problems biology and medicine» Issue 4 (167), 2022 year, 281-284 pages, index UDK 616.831.7-071-072

10.29254/2077-4214-2022-4-167-281-284