ФАРМАКОДИНАМИКА И СПЕКТР ДЕЙСТВИЯ ИНДОЛ-3-КАРБИНОЛА

Зайченко А. В., Горчакова Н. А., Синицына О. С., Зайченко В. С., Равшанов Т. Б.

ОБЗОРЫ ЛИТЕРАТУРЫ

Научная статья.

Из овощей растений семейства крестноцветных были выделены глюкозинолаты, из которых получили и в дальнейшем экспериментально исследовали индол-3-карбинол. Приведены данные относительно малой токсичности и безопасности индол-3-карбинола. Механизм действия этого соединения сложный, связанный с влиянием на разные компоненты сигнальных систем, прооксидантно/антиоксидантный гомеостаз, метаболизм эстрогенов, активность ряда ферментов. Показано, что в опухолях молочной железы, матки, яичников, печени, легких, простаты. Механизм действия индол-3-карбинола опосредован влиянием на процессы пролиферации, ангиогенеза, апоптоза. В тканях меланомы индол-3-карбинол влияет преимущественно на BRAF-экспрессирующие клетки, угнетает процессы пролиферации, обладает противовоспалительным действием. Показана эффективность индол-3-карбинола при папилломатозе матки, вагины, вульвы, а также при респираторном папилломатозе. Экспериментально доказана возможность применения индол3-карбинола при ишемическом инсульте, колите. Приведенные экспериментальные и клинические данные являются основанием для разработки на его основе новых лекарственных препаратов с широким спектром фармакологического действия.

индол-3-карбинол, механизмы противоопухолевого действия, противовоспалительная, антитромботическая, антиоксидантная активность

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«Вестник проблем биологии и медицины» Выпуск 3 (145), 2018 год, 30-38 страницы, код УДК 618.14-002+618.14-006.36

10.29254/2077-4214-2018-3-145-30-38