Голотюк В. В.

ПЕРСПЕКТИВЫ ПРИМЕНЕНИЯ МОДИФИКАЦИЙ ПЕКТИНА В КОМПЛЕКСЕ МЕДИКАМЕНТОЗНОЙ ТЕРАПИИ РАКА ТОЛСТОЙ КИШКИ


Об авторе:

Голотюк В. В.

Рубрика:

ОБЗОРЫ ЛИТЕРАТУРЫ

Тип статьи:

Научная статья.

Аннотация:

Альтернативой парентеральному введению химиотерапевтических препаратов при лечении больных колоректальным раком все чаще становится применения лекарственных форм для перорального приема. Таким образом можно достичь уменьшения дозы лекарственных препаратов и системных побоч-ных эффектов. Учитывая, что специфическая микрофлора толстого кишечника выборочно переваривает пектин, последний может быть использован в качестве специфического средства для локальной доставки лекарственных средств, предотвращая их высвобождение в верхних отделах желудочно-кишечного тракта. Пектин рассматривают не только как носитель лекарственного средства, но и в качестве терапевтического агента в лечении и профилактике колоректального рака.

Ключевые слова:

пектин, колоректальный рак, лечение, химиотерапия

Список цитируемой литературы:

  1. Amidon S, Brown JE, Dave VS. Colon-targeted oral drug delivery systems: design trends and approaches. AAPS Pharm Sci Tech. 2015;16(4):731-41.
  2. Beloqui A, Coco R, Memvanga PB, Ucakar B, des Rieux A, Préat V. pH-sensitive nanoparticles for colonic delivery of curcumin in inflammatory bowel disease. Int J Pharm. 2014 Oct 1;473(1-2):203-12.
  3. Chaurasia M, Chourasia MK, Jain NK, Jain A, Soni V, Gupta Y, et al. Methotrexate bearing calcium pectinate microspheres: a platform to achieve colon-specific drug release. Curr Drug Deliv. 2008 Jul;5(3):215-9.
  4. Cheewatanakornkool K, Niratisai S, Manchun S, Dass CR, Sriamornsak P. Thiolated pectin-doxorubicin conjugates: Synthesis, characterization and anticancer activity studies. Carbohydr Polym. 2017 Oct 15;174:493-506.
  5. Chourasia MK, Jain SK. Pharmaceutical approaches to colon targeted drug delivery systems. J Pharm Pharm Sci. 2003;6(1):33-66.
  6. Farkouh A, Scheithauer W, Buchner P, Georgopoulos A, Schueller J, Gruenberger B, et al. Clinical pharmacokinetics of capecitabine and its metabolites in combination with the monoclonal antibody bevacizumab. Anticancer Res. 2014 Jul;34(7):3669-73.
  7. Gazzaniga A, Maroni A, Sangalli ME, Zema L. Time-controlled oral delivery systems for colon targeting. Expert Opin Drug Deliv. 2006 Sep;3:583-97.
  8. Glinsky VV, Raz A. Modified citrus pectin anti-metastatic properties: one bullet, multiple targets. Carbohydr Res. 2009;344:1788-91.
  9. Henaine AM, Chahine G, Salameh P, Elias E, Massoud M, Hartmann D, et al. Management of metastatic colorectal cancer: Current Treatments and New Therapies. J Med Liban. 2015 Oct-Dec;63(4):218-27.
  10. Itoh K, Yahaba M, Takahashi A, Tsuruya R, Miyazaki S, Dairaku M, et al. In situ gelling xyloglucan/pectin formulations for oral sustained drug delivery. Int J Pharm. 2008 May 22;356(1-2):95-101.
  11. Jain A, Gupta Y, Jain SK. Potential of calcium pectinate beads for target specific drug release to colon. J Drug Targeting. 2007;15(4):285-94.
  12. Jain SK, Jain A. Target-specific drug release to the colon. Expert Opin Drug Deliv. 2008;5(5):483-98.
  13. Komatsu Y, Harada K, Fukushima H, Yuki S. New molecular targeting drugs for metastatic colorectal cancer. Nihon Rinsho. 2014;72(1):120-6.
  14. Kumar P, Mishra B. Colon targeted drug delivery systems – an overview. Curr Drug Deliv. 2008;5(3):186-98.
  15. Liu J, Zhang L, Jia Y, Hu W, Zhang J, Jiang H. Preparation and evaluation of pectin-based colon-specific pulsatile capsule in vitro and in vivo. Arch Pharm Res. 2012 Nov;35(11):1927-34.
  16. Liu Y, Zhou H. Budesonide-loaded guar gum microspheres for colon delivery: preparation, characterization and in vitro/in vivo evaluation. Int J Mol Sci. 2015;16(2):2693-704.
  17. Lu WQ, Wang F, Liu HY. Influence of oxaliplatin combined with LCP on proliferation and apoptosis of colon cancer cell line HT29. Zhonghua Wei Chang Wai Ke Za Zhi. 2013;16(1):84-8.
  18. Maestrelli F, Cirri M, Corti G, Mennini N, Mura P. Development of enteric-coated calcium pectinate microspheres intended for colonic drug delivery. Eur J Pharm Biopharm. 2008 Jun;69:508-18.
  19. Midgley RS, Merrie A, Kerr DJ. Colorectal cancer: a multidisciplinary approach. Clinical gastroenterology and hepatology. 2005;60:421-30.
  20. Nakahara S, Raz A. Regulation of cancer-related gene expression by galectin-3 and the molecular mechanism of its nuclear import pathway. Cancer Metastasis Rev. 2007;26:605-10.
  21. Prado SBRD, Ferreira GF, Harazono Y, Shiga TM, Raz A, Carpita NC, et al. Ripening-induced chemical modifications of papaya pectin inhibit cancer cell proliferation. Sci Rep. 2017 Nov 29;7(1):16564.
  22. Saito D, Nakaji S, Fukuda S, Shimoyama T, Sakamoto J, Sugawara K. Comparison of the amount of pectin in the human terminal ileum with the amount of orally administered pectin. Nutrition. 2005 Sep;21:914-9.
  23. Sakamoto J, Oba K, Matsui T, Kobayashi M. Efficacy of oral anticancer agents for colorectal cancer. Dis Colon Rectum. 2006 Oct;49:82-91.
  24. Sanz-Garcia E, Grasselli J, Argiles G, Elez ME, Tabernero J. Current and advancing treatments for metastatic colorectal cancer. Expert Opin Biol Ther. 2016;16(1):93-110.
  25. Song M, Garrett WS, Chan AT. Nutrients, foods, and colorectal cancer prevention. Gastroenterology. 2015;148(6):1244-60.
  26. Szente V, Zelkó R. Site-specific drug delivery systems. I. Colon targeted delivery. Acta Pharm Hung. 2007;77(3):185-89.
  27. Wei X, Sun N, Wu B, Yin C, Wu W. Sigmoidal release of indomethacin from pectin matrix tablets: Effect of in situ crosslinking by calcium cations. Int J Pharm. 2006 Aug 2;318:132-8.
  28. Wikiera A, Irla M, Mika M. Health-promoting properties of pectin. Postepy Hig Med Dosw (Online). 2014;68:590-6.
  29. Wong JM, de Souza R, Kendall CW, Emam A, Jenkins DJ. Colonic health: fermentation and short chain fatty acids. J Clin Gastroenterol. 2006;40:235-43.
  30. Wong TW, Nurjaya S. Drug release property of chitosan-pectinate beads and its changes under the influence of microwave. Eur J Pharm Biopharm. 2008;69:176-88.
  31. Wu B, Deng D, Lu Y, Wu W. Biphasic release of indomethacin from HPMC/pectin/calcium matrix tablet: II. Influencing variables, stability and pharmacokinetics in dogs. Eur J Pharm Biopharm. 2008 May;69:294-302.

Публикация статьи:

«Вестник проблем биологии и медицины» Выпуск 1 Том 1 (142), 2018 год, 25-30 страницы, код УДК 616-006.6+615.28+547.458.88

DOI: