СОСТОЯНИЕ ЭКСТРАЦЕЛЛЮЛЯРНОГО МАТРИКСА И МЕЖКЛЕТОЧНОЙ АДГЕЗИИ В ЭМБРИОНАЛЬНОМ РАКЕ ЯИЧКА

Потапов С. Н., Галата Д. И., Плитень О. Н., Сидоренко Р. В., Андреев А. В.

ПАТОМОРФОЛОГИЯ

Научная статья.

В статье изложены данные о состоянии экстрацеллюлярного матрикса и межклеточной адгезии в эмбриональном раке яичка. Показано, что при его прогрессировании увеличиваются площадь и интенсив-ность экспрессии маркеров MMP-1, MMP-3 и MMP-9 при отсутствии экспрессии TIMP-1, снижается площадь экспрессии E-cadherin и увеличивается площадь экспрессии β-catenin в сочетании с атипичной локализацией данных маркеров. Изученные маркеры могут быть независимыми факторами прогноза метастазирования и прогрессии эмбрионального рака яичка.

эмбриональный рак яичка, экстрацеллюлярный матрикс, межклеточная адгезия, иммуногистохимическое исследование.

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«Вестник проблем биологии и медицины» Выпуск 4 том 1 (153), 2019 год, 246-254 страницы, код УДК 616.61 – 006.6 – 018.1 – 092.18

10.29254/2077-4214-2019-4-1-153-246-254