THE HUMORAL LINK OF IMMUNE DEFENSE IN EXPERIMENTAL BACTERIAL-IMMUNE PERIODONTITIS
About the author:
Demkovych A. Ye., Bondarenko Yu. I., Hasiuk P. A.
Heading:
DENTISTRY
Type of article:
Scentific article
Annotation:
Objective – to elucidate the pathogenetic role of the humoral link immune reactivity in the dynamics of the inflammatory response in experimental bacterial-immune periodontitis. In blood serum the level of Ig A, Ig M, Ig G and the concentration of circulating immune complexes (CIC) was determined. The results were statistically analysed with using nonparametric indexes. At the early stage of experimental periodontitis development, that is, in the period of acute manifestations, on the 7th day, the concentration of the main classes of immunoglobulins (A, M, G) in the blood serum was increased, however, on the 14th day of observation, the concentration of Ig A and G was changed in the opposite direction, that is, to decrease, and the level of immunoglobulin M class, on the contrary, was increased. On the 30th day of observation, Ig A and Ig M levels was increased as compared to the 14th day, however, Ig G concentration changed in the opposite direction, that is, decreased. At the same time the contents of the CIC in blood serum was measured as an important element in the pathogenesis of immune damage for experimental inflammation in periodontal tissues. The dynamic of the CIC concentration were similar to the dynamic of the immunoglobulins, that is, on the 7th day of the experiment, their concentration was more larger and subsequently began to decline. It`s investigated of the functional state of immune defense in white rats with simulated bacterial-immune periodontitis, disorders of the humoral element of immunological reactivity were revealed, which were manifested in accordance to the period of the inflammatory reaction development in the periodontal complex.
Tags:
bacterial-immune periodontitis, immunoglobulins, circulating immune complexes, immune status
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Publication of the article:
«Bulletin of problems biology and medicine» Issue 1 Part 2 (143), 2018 year, 351-355 pages, index UDK 616.314.17-008.1-022.7-085-091.8]-092.9