MORPHOMETRIC CHANGES OF HEART IN OBESIGN AND AFTER SURGICAL TREATMENT
About the author:
Duka R. V., Kosharny V. V., Abdul-Ogli L. V., Kushnaryova K. A.
Heading:
MORPHOLOGY
Type of article:
Scentific article
Annotation:
Obesity provokes the acceleration of the development of factors that make up the cardiovascular risk in general. Obesity and arterial hypertension potentiate one another in relation to the development of an adverse effect on the structure and function of the heart, increases the level of pre- and post-load on the heart, especially in people with severe and prolonged (> 15 years) obesity; the risk of the formation of GMSH from 5.5% in people with normal body weight up to 29.9% in obese people is increasing. When joining the obesity of hypertension, the risk of hypertrophy of the heart increases more than 4 times. The problem of overweight is the scourge of our time. Obesity is diagnosed quite often. Therefore, the conservative approach is not always rational. Surgical treatments for obesity are never more relevant than ever. Purpose. To establish morphometric changes in the heart during obesity and after surgical treatment. Object and methods. We were modeling obesity according to the standard method of high-calorie nutrition, within a month. The weight of rats was 380-400 g. Surgical treatment was performed by resection of the stomach in large curvature. Results and discussion. As a result of our research, we observed changes in the heart wall at all levels of the organization. At 30 days from the beginning of the experiment, a comprehensive heart study was conducted using morphometric studies at all levels of the structural organization. After removing the heart from the thoracic cavity, it was weighed, the mass on average equaled: 2.10 ± 0.025 g. The index of the ratio of the mass of the heart to the weight of the rat was 0.54. To determine the shape of the heart of rats, we calculated the index of the ratio of the width of the heart to its length (F). In 85% of cases, the obesity of the rats’ heart rats was globular, the index (F) amounted to an average of 86%, with an ellipsoidal pattern of 9%, an index of more than 65%. Cone-shaped form was observed in 6% of cases. At 30 days from the beginning of the experiment, the analysis of the thickness of the wall of the heart at various levels showed that the highest rates were in the middle third of the heart, it was observed in both the right and left ventricles of the heart. Analyzing the thickness of the ventricular wall, it was found that changes occurred unevenly at different levels, and the greatest changes in the indicators compared with the control occurred in the middle third. In the interventricular lining, the average third changed more. The thickness of the anterior wall of the left ventricle was 3.8 ± 0.1 mm, the back wall was 3.9 ± 0.11 mm, the side wall 3.1 ± 0.08 mm, the interventricular membrane 3.6 ± 0.09 mm in the right ventricle the thickness of the front wall is 1,26 ± 0,04 mm, the back wall 1,56 ± 0,06 mm. The cross-sectional area of the right and left ventricles of the rat’s heart was equal to the left ventricle of 535.0 ± 4.2 mm2, in the right ventricle 125.0 ± 3.1 mm2. Conclusions 1. When obesity is dominated by a globular form of the heart, 85% of all forms of heart are affected by this form. 2. When obesity of the heart weighs 3.44 times, with resection of the stomach, its weight decreases by 1.75 times. 3. The cross-sectional area of the left ventricle, after resection of the stomach, decreased by 20 mm2, the right ventricle by 11 mm2. All these pathological changes that are traced confirm the positive changes in resection of the stomach on the cardiovascular system, in particular the heart.
Tags:
obesity, heart, morphometry
Bibliography:
- VOZ Ozhireniye i izbytochnyy ves. Informatsionnyy byulleten’. 2011;311 [Internet]. Dostupno: http://www.who.int/mediacentre/factsheets/ fs311/ ru/index.html/ [in Russiаn].
- Belenkov YuN, Dzheriyeva IS, Rappoport SI, Volkova NI. Metabolicheskiy sindrom kak rezul’tat obraza zhizni. M.: MIA; 2015. 240 s. [in Russiаn].
- Freedman D, Ron E, Ballard-Barbash R. Body mass index and all-cause mortality in a nationwide US cohort. Int. J. Obes (Lond.). 2006;30:822-9.
- Dedov II. Morbidnoye ozhireniye. M.: 2014. 608 s. [in Russiаn].
- Peretolchina TF, Dashutina SYu, Barats SS. Ozhireniye i morfofunktsional’nyye izmeneniya serdtsa: Obzor. Kardiologiya. 2005;7:66-8. [in Russiаn].
- Shlyakhto YeV, Konradi AO, Zakharov DV, Rudomanov OG. Strukturno-funktsional’nyye izmeneniya miokarda u bol’nykh gipertonicheskoy bolezn’yu. Kardiologiya. 1999;2:49-55. [in Russiаn].
- Yegiyev VN. Umen’shayushchaya rezektsiya zheludka v lechenii morbidnogo ozhireniya. Endoskopicheskaya khirurgiya. 2007;1:42. [in Russiаn].
- Yudin VA, Usachev IA, Mel’nikov AA. Khirurgicheskoye lecheniye bol’nykh morbidnym ozhireniyem. Rossiyskiy biologicheskiy vestnik imeni akademika I.P. Pavlova. 2013;2:111-8. [in Russiаn].
Publication of the article:
«Bulletin of problems biology and medicine» Issue 3 (145), 2018 year, 282-284 pages, index UDK 616-092:613.25-089