MICROSATELLITE INSTABILITY IN DIFFERENT HISTOLOGICAL TУPES OF COLON POLYPES WITH ASYMPTOMATIC HYSTORY

Varyvoda O. Yu.

PATHOMORPHOLOGY

Scentific article

According to many researchers, CRC most often occurs in the background of polyposis lesion. The aim of the work was to determine the status of MSI in colon polyps, to determine the frequency of polyposis of the colon in asymptomatic patients, to determine the sex-age, histological rate of types and the distribution by localization of the identified polyps. As a result of the study, 32% (64 persons) of asymptomatic patients had been diagnosed polyposis lesions of the colon, of which 8 cases had cancer (12.5%), which is a rather significant proportion of the total. In the share of potentially dangerous polyps, in terms of the development of cancer, 29 cases (45.3%) occurred, which again confirms the need for preventive screenings of the adult population. An immunohistochemical investigation showed the presence of MSI in one case of cancer, where none of the proteins has reacted, which we can consider as a high-level MSN. Expression of MLH-1 protein in the group “Adenoma Minimal Dysplasia” was significantly lower (57.14 ± 18.70%) (p <0.05) compared to the groups “Hyperplastic polyps” and “Adenomy maximal dysplasia”. Expression of MSH-2 protein in the “Adenoma Minimal Dysplasia” group was significantly (p <0.05) lower (2.29 ± 0.30) compared to the group “Hyperplastic Polyps”, where the figure was 3.00 ± 0.00. Expression of the MSH-6 protein was the highest in the Adenoma maximal dysplasia group (3.00 ± 0.00) and significantly (p <0.05) exceeded this figure in the Hyperplastic Polyps group, where it was 2.14 ± 0.30. High expressions of MSH-6 protein expression in the “Hyperplastic Polyps” group give reason to reconsider the significance of these polyps in the development of carcinoma, since they have not been considered as precancerous. The obtained results allow to increase the quality of premorbid diagnostics of CRC development in patients with asymptomatic course of polyposis of the colon and, in the future, to introduce recommendations for predicting the development of malignant transformations of polyps.

polyps, adenomas, colorectal cancer, microsatellite instability

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«Bulletin of problems biology and medicine» Issue 3 (145), 2018 year, 345-349 pages, index UDK 616.345-006.6-076.5:616.345-006.5

10.29254/2077-4214-2018-3-145-345-349