DYSLIPIDEMIA AND ENDOTHELIAL DYSFUNCTION IN THE PATHOGENESIS OF NONALCOHOLIC STEATOHEPATITIS IN PATIENTS WITH OBESITY AND CHRONIC KIDNEY DISEASE
About the author:
Antoniv A. A.
CLINICAL AND EXPERIMENTAL MEDICINE
Type of article:
The aim of the study – to find out the features of the lipid blood spectrum and the development of endothelial dysfunction in non-alcoholic steatohepatitis in patients with obesity and chronic kidney disease. Object and methods of research. 135 patients were examined: of which 52 patients with non-alcoholic steatohepatitis with obesity I degree (1 group), 53 patients with non-alcoholic steatohepatitis with comorbid obesity of the I degree and chronic kidney disease of the І-ІІ stage (group 2). The control group consisted of 30 practically healthy persons of the corresponding age and sex. The average age of patients was (45.8 ± 3.81) years, men were 48, and women 57 persons. Results of research and their discussion. As a result of studies, it was found that patients with non-alcoholic steatohepatitis on the background of obesity are characterized by lipid distress syndrome with an increase in total cholesterol in blood, low density proatherogenic lipoprotein, deficiency of anti-atherogenic high-density lipoproteins. The role of nitrosative stress in the pathogenesis of nonalcoholic steatohepatitis, the confirmation of which is the increase in the concentration of nitrosothiols, peroxynitrite and other metabolites NO in the blood. Conclusion. Thus, with the comorbid flow of non-alcoholic steatohepatitis and chronic kidney disease of the І-ІІ stage, on the background of obesity, a deeper lipid imbalance, hypercholesterolemia, including in the low density lipoprotein, a decrease in the content of high density lipoprotein, an increase in the atherogenicity index, and hyperproduction of the endothelium and lymphocytes from the progressive damage to the endothelium.
non-alcoholic steatohepatitis, chronic kidney disease, obesity, lipid profile, endothelial dysfunction
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Publication of the article:
«Bulletin of problems biology and medicine» Issue 4 part 1 (146), 2018 year, 45-47 pages, index UDK 616.36-003.826:616.379-008.64]:577.12+616.61-036.12