EXPERIENCE WITH TAKING CARE OF HYPERPROLACTINEMIA PATIENTS DURING PREVENTION FOR ASSISTED REPRODUCTIVE TECHNOLOGIES

Nikiforov O. A., Lomeiko E. A., Avramenko N. V.

CLINICAL AND EXPERIMENTAL MEDICINE

Scentific article

The aim – to research the results of diagnostic and treatment male infertility during hyperprolactinemia and preparing for assisted reproductive technologies are presented at the article. Object and methods. 58 men were included in the research. It was formed two different groups – with normoprolactinemia (27 persons, group 1) and hyperprolactinemia (21 persons, group 2). It has done the typical clinical and biochemical investigation in all patients. For the research of spermogram parameters it was used the method of luminescent microscopy. At the patients with hyperprolactinemia the magnetic resonant tomography or computed tomography for diagnostics of hypophysis adenomas was used. At 19 patients with male infertility and hyperprolactinemia was used semisynthetic alkaloid bromocriptine for systemic treatment (the dosage 2,5 mg twice per day during 4 weeks). Results. It is set that hyperprolactinemia causes the reliable changes of spermogram parameters with the reduction of concentration (р<0,05) and numerous of spermatozoas (р<0,05), decreasing of normokinetic forms (р<0,05), increasing of hypokinetic (р<0,05) and akinetic (р<0,05) forms, morphologically it was set the reduction of normal cells (р<0,05) and presenting of degenerative cells (р<0,05). It is revealed, that usage of bromocriptine for male infertility with hyperprolactinemia promotes the decline of prolactin level (р<0,05), increases the follicle-stimulating hormone (р<0,05) and luteotrophic hormone (р<0,05), and also the level of testosterone and testosterone/oestrogen (р<0,05) ratio. It is proved that bromocriptine application at the men with hyperprolactinemia stimulates the processes of spermatogenesis with the reliable increase of spermatozoas number (р<0,05), especially normokinetic forms (р<0,05), with the reduction of hypokinetic (р<0,05) and akinetic (р<0,05) spermatozoas, and also with the reduction of degenerative forms (р<0,05). Conclusion. The male patients with infertility and hyperprolactinemia have reliable changes of spermogram parameters with the reduction of concentration and numerous of spermatozoas, normokinetic forms, increasing of hypokinetic and akinetic forms, morphologically. Bromocriptine implementation during male infertility with hyperprolactinemia gives a good results for processes of spermatogenesis, so it could be high effective during additional reproductive technologies.

male infertility, hyperprolactinemia, spermogram, bromocriptine

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«Bulletin of problems biology and medicine» Issue 4 Part 3 (141), 2017 year, 177-180 pages, index UDK 616.432-006-08

10.29254/2077–4214–2017–4–3–141–177-180