ACTION OF TREATMENT AND PREVENTION COMPLEX ON DYNAMICS OF PERIODONTAL TISSUES, CHANGES OF BIOCHEMICAL MARKERS OF ORAL FLUID AND HORMONAL STATUS IN WOMEN WITH POLYCYSTIC OVARIAN SYNDROME

Dizik S. V., Romanova Yu. G., Volyanska A. G., Lunko T. A.

DENTISTRY

Scentific article

Purpose of research – evaluation of dynamics of periodontal tissues changes, biochemical markers of oral fluid and hormone status of women with polycystic ovarian syndrome (POS) under the action of treatment and prevention complex (TPC), which includes phytoestrogens and antioxidants. Object and methods. Fertile 75 women were conducted clinical stomatological examination and laboratory analysis. Of them 50 women had generalized periodontitis and POS (basic group) and 25 women without POS with intact periodontium (a control group). The basic group was divided into 2 sub-groups by 25 persons (IA and IB). The IA sub-group was treated with TPC with phytoestrogens and antioxidants. The IB sub-group was treated with traditional methods. The level of urease, catalase, glutathionperoxidase, lysocyme, superoxide dismutase, diene conjugates, malonic dialdehyde were determined during the clinical observation in the oral fluid of women. The level of hormones (LH, FSH, prolactin, testosteron and estradiol) in the blood serum was determined with the help of immune chemoluminescent analysis. Results of research. The dynamic observation after the women with POS during 12 months from the beginning of developed TPC application confirmed its efficiency. The value of the CPI index significantly decreased in IA group women from 5.3±0.3 up to 3.0±0.4, PMA index (%) decreased tree folds – from 48% to 18%, SBI gingival bleeding index – from 3.4±0.21 up to 1.1±0.08. The research of oral fluid biochemical markers dynamics in women with POS and generalized periodontitis, treated with TPC, revealed the gradual decrease in the oral fluid of diene conjugates, malonic dialdehyde, activity of superoxide dismutase, glutathionperoxidase and increase of lysozyme. A positive dynamics was noted in the hormonal status of women with POS under the action of TPC, which manifested itself in tendency to the rise of estradiol level and decline of testosteron level in blood serum. Results. Application of pathogenetically proved TPC for treatment of generalized periodontitis in women with POS confirmed its clinical efficiency, the stage of stable remission of disease was achieved. Biochemical researches revealed positive influence of the developed TPC on homeostasis of oral cavity and hormonal status of patients with POS.

generalized periodontitis, treatment and prevention complex, polycystic ovarian complex, sex hormones, oral liquid, biochemical markers

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«Bulletin of problems biology and medicine» Issue 4 Part 3 (141), 2017 year, 344-348 pages, index UDK 616.311/314.17-06:618.11-006]-074/078-08

10.29254/2077–4214–2017–4–3–141–344-348