CHANGES IN OXYGEN-TRANSPORT SYSTEM AND STRUCTURAL REHABILITATION OF ERYTHROCYTES DURING CARDIOVASCULAR INSUFFICIENCY AGAINST DEFICIT VITAMIN D

Barila N. I.

CLINICAL AND EXPERIMENTAL MEDICINE

Scentific article

Cardiorespiratory endurance is a reflection of the functional reserves of the respiratory and cardiovascular systems and therefore performs a protective function in various pathologies of both these systems and the body as a whole, especially when vitamins are insufficient. At the same time, the adaptation of the organism to the effects of various environmental factors (for example, physical activity) requires a large expenditure of the energy potential of the organism, which largely depends on the intensity of oxidative phosphorylation. The deficit of oxygen and vitamin D, as well as the energy required for resynthesis of ATP, increases the cost of adaptation of the body to physical exertion and can lead to significant damage to cellular structures. In order to differentiate the amount of physical activity and avoid its negative effects on the human body, there is a need for a comprehensive study of the impact of aerobic exercise on morpho-functional changes in the oxygen-transport system in patients with chronic heart failure on the background of vitamin D deficiency. The aim of the study is to identify the nature of the morpho-functional changes in the oxygen-transport system of patients with different levels of cardiorespiratory endurance in the conditions of performing a 6-minute test with walking with a deficiency of vitamin D. Methods. 80 patients aged 50-65 years were examined to establish the excursion and ventilation function of the lungs, blood gas composition, lipid peroxide activity, 2,3-DFG and ATP levels, vitamin D levels and the morphological state of the erythrocytes of peripheral blood. Results. Patients with low levels of cardiorespiratory endurance against vitamin D deficiency after physical activity show changes in flow-to-volume parameters against the background of an increase in lactate concentration and a decrease in acid-base balance, which leads to an increase in 2,3-DFG in peripheral blood erythrocytes. Conclusion. It has been established that in patients with low cardiorespiratory endurance on the background of vitamin D deficiency during the 6-minute walk test, the increase in ventilation is mainly due to an increase in respiratory rate, which leads to rapid respiratory muscle fatigue and, consequently, ventilation and gas exchange. This decreases the level of blood oxygenation, decreases the intensity of oxidative phosphorylation and ATP resynthesis, which leads to the appearance of atypical forms of peripheral blood erythrocytes.

chronic heart failure, vitamin D, hemoglobin, erythrocytes, hypoxia, gas exchange.

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«Bulletin of problems biology and medicine» Issue 2 Part 2 (151), 2019 year, 82-87 pages, index UDK 612.111+616-072.5 +612.015.6+616.12

10.29254/2077-4214-2019-2-2-151-82-87