ANALYSIS OF THE RESULTS OF THE TREATMENT OF ASTHMA IN SCHOOL-AGE CHILDREN SENSITIZED TO CAT ALLERGENS

Kryvopustova M. V.

PATHOMORPHOLOGY

Scentific article

. In school-age children, sensitization to cat allergens is strongly associated with asthma, which is of great medical and social importance. The aim of the study is to evaluate the results of treatment of asthma in school-age children sensitized to cat allergens and to determine the role of allergen-specific immunotherapy. The study with dynamic follow-up for 12 months included 128 children aged 6-17 years who were diagnosed with asthma and sensitized to at least one of the following allergens in cats Fel d 1, Fel d 2, Fel d 4, Fel d 7. Skin prick test, multicomponent molecular allergy diagnostics (ALEX² test), spirometry and a study of the content of nitric oxide in the exhaled air were carried out. Statistical analysis was performed using IBM SPSS Statistics Base (version 22). There is a direct correlation between achieving asthma control after 12 months of treatment and controller treatment (r=0.563; p<0.001) and allergen-specific immunotherapy (r=0.245; p<0.001). The asthma control test in children aged 6-11 and 12-17 years was differentiated. After 9 months of treatment, the difference in the median value of this indicator between the group of patients who received allergen-specific immunotherapy on the background of controller treatment and the group of patients who received only controller treatment, reached statistical significance (p=0.005). Also, after 9 months of treatment, the difference in the mean volume of forced expiratory volume in the first second between these groups reached statistical significance (p=0.043). The dynamics of peak expiratory flow were identical. The difference in the value of the average content of nitric oxide in the air that the child exhales between these groups of patients reached statistical significance (p=0.012) at the visit at 12 months. Allergen-specific immunotherapy on the background of controller treatment of asthma in school-age children with sensitization to cat allergens leads to improved treatment outcomes.

asthma, school-age children, treatment, sensitization to cat allergens.

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«Bulletin of problems biology and medicine» Issue 2 Part 2 (165), 2022 year, 192-200 pages, index UDK 616.248-053.5-022.9:599.742.7-08-039.73

10.29254/2077-4214-2022-2-2-165-192-200