INFLUENCE OF ODONTOPREPARATION TYPE FOR METAL-CERAMIC CONSTRUCTIONS ON CYTOKINE PROFILE DYNAMICS IN ORAL AND GINGIVAL FLUID

Popovich I. Yu.

LITERATURE REVIEWS

Scentific article

Abstract. Introduction. The article gives an overview of the scientific literature on the results of a cytological study of the level of proinflammatory cytokines in the oral and gingival fluid, depending on the type of odontopreparation for cermet structures. Purpose. Analyze literature sources with a characteristic of the level of mediators of proinflammatory processes in the oral and gingival fluid, depending on the type of odontopreparation for cermet structures.Results. At the clinical stages of the preparation of teeth for prosthetics with non-removable orthopedic structures, a local immune response to the acute stimulus appears in the marginal periodontium.This is confirmed in laboratory by preclinical manifestations of signs of the inflammatory process by developing an imbalance in the cytokine background. The main pro-inflammatory cytokine is IL-1, the main anti-inflammatory cytokine is IL-10. IL-1 is divided into 2 fractions – IL-1α and IL-1β. The induction of IL-1 synthesis can be caused by a number of biologically active substances, the main of which are the components of the cell walls of bacteria, as well as antigens, immune complexes, cytokines, cell-decay products. In the presence of an irritating factor, the concentration of IL-1β increases several times, while the level of anti-inflammatory cytokines is in a state where the balance of the body’s own forces can not be restored. IL-10 is an inhibitor of inflammation and a cytokine cascade. It inhibits the synthesis of cytokines of T-helpers 1, chemokines, adhesion molecules, suppresses the synthesis of monocyte-macrophage tumor necrosis factor TNFα, IL-1, IL-6, IL-12, granulocyte colony-stimulating factor. Thus, the main function of IL-10 is the restriction and suppression of the inflammatory process. Conclusions. The main clinical manifestations of periodontal diseases directly depend on the activity of immunity cells. By influencing the processes and mechanisms of regeneration, regulating the balance of proinflammatory and anti-inflammatory cytokines, it becomes possible to influence the development of periodontal diseases by suspending their progression.

proinflammatory cytokines, inflammatory regulators, IL-1α, IL-1β, TNF-α.

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«Bulletin of problems biology and medicine» Issue 4 (162), 2021 year, 61-65 pages, index UDK 316.314.-2

10.29254/2077-4214-2021-4-162-61-65