CHANGES OF THE HEMOCAPILLARY LEVEL OF THE ADRENAL GLANDS UNDER CONDITIONS OF BURN INJURY

Pastukhova V. A., Lukyantseva G. V., Titarenko V. M., Dutchak V. M.

MORPHOLOGY

Scentific article

The results of experimental modeling of thermal burn injury in adult male rats showed a number of degenerative and destructive structural and functional changes in the blood vessels of the cortical and cerebral matter of the adrenal glands in the dynamics of the study. One day after the simulation of thermal burns, there are initial, insignificant changes in hemocirculatory parameters with preservation of the histoarchitectonics of the adrenal gland, the greatest degree of these changes was registered three days after simulation of the burn. In all terms of the experiment (1, 3 and 7 days after simulation of thermal burns) the general morphological organization of the cortical and cerebral matter of the adrenal glands was preserved, but the presence of significant adverse disorders of regional microcirculation was found. The histomorphometric analysis of the dynamics of changes in the obtained data showed a stable vasodilation in the period from 1 to 3 days and a tendency to reduce the lumen of blood microvessels in the subsequent period of the study. While maintaining the general histoarchitectonics of the main connective tissue structural elements around blood vessels, at the border between the reticular zone of the cortex and the brain, an increase in interstitial space is associated with the development of paravasal edema on the background of altered microcirculation. The main morphological manifestations of impaired microcirculation after simulation of thermal burn injury in our study were significant erythrocyte stasis, dilatation of hemocapillaries and sinusoidal venules, mainly in the adrenal medulla. At all times of the observation, there was a significant increase in the cross-sectional area of the venous sinusoids, mainly in the cerebral substance of the adrenal glands. In cases of acute hemodynamic disorders, necrosis of cellular elements of the adrenal medulla was registered.

thermal burn, adrenal glands, microcirculation.

1. Protsenko OS, Shapoval OV, Teslenko HO, Rodionov MO, Voshchylin BR, Yeletskyi MS. Klinichni ta eksperymentalni doslidzhennia tkanyn pry termichnykh poshkodzhenniakh. Aktualni problemy suchasnoi medytsyny. 2019;3:4-13. DOI: 10.26565/2617-409X-2019-3-01. [in Ukrainian].
2. Sorokina OYu, Filip ZhV. Porivnialna kharakterystyka dynamiky pokaznykiv metabolichnoi vidpovidi u fazy perebihu opikovoi khvoroby zalezhno vid terminiv pochatku operatyvnoho likuvannia. Klinichna medytsyna. 2017;18(XXIII):42-9. [in Ukrainian].
3. Tejiram S, Romanowski KS, Palmieri TL. Initial management of severe burn injury. Curr Opin Crit Care. 2019 Dec;25(6):647-52.
4. Gupta JL. Ten commandments of burn management. J. Burns. 2012;20:7-10.
5. Mino MJ, Ortiz RT, Randad P, Moffatt LT, Jordan MH, Shupp JW. Localization of Superantigen Virulence Factors in Kidney Tissue of Animals With Staphylococcus aureus-Infected Burn Wounds. J of Burn Care & Research. 2013;34:142-50.
6. Lakhtadyr TV. Strukturni zminy kirkovoyi rechovyny nyrok shchuriv u pizni terminy pislya opikovoyi travmy shkiry za umov infuziyi HAESLX5%. Svit medytsyny ta biolohiyi. 2017;3(61):120-7. [in Ukrainian].
7. Guminskiy YuI, Gunas IV, Ocheretna NP, Bashinska OI. Micromorphometric changes in rats spleen in the first 7 days after skin burns and under application of infusion solutions. Visnyk morfolohiyi. 2017;23(2):240-4.

«Bulletin of problems biology and medicine» Issue 4 (162), 2021 year, 272-275 pages, index UDK 616-001.17 + 616. 45

10.29254/2077-4214-2021-4-162-272-275