BIOCHEMICAL INDICATORS OF ORAL FLUID IN PATIENTS WITH CHRONIC CATARRHAL GINGIVITIS AND PRIMARY GENERALIZED PERIODONTITIS AND I-I POWER

Ostrovsky A. V.

CONTENTS

Scentific article

In recent years the structure of disease periodontal undergone significant changes observed earlier manifestation of periodontitis and periodontal disease, the growth rate of identify “aggressive” forms of periodonti-tis (juvenile, progres siruyuschy). This indicates Vaeth the need for further study of the general and local risk factors, clarifying the structure and features of clinical manifestations periodontal disease in young people in order to plan treatment and preventive measures. The purpose of this study was to investigate the biochemical indicators of oral fluid in patients with chronic catarrhal gingivitis and generalized periodontitis of the initial I -I and power to justify and al-gorithm development of professional oral hygiene in patients with inflammatory periodontal diseases. Object of study: oral fluid in young adults (18-35 years) with inflammatory periodontal diseases. Fence research material produced in patients in the morning at the same time, an empty stomach. In the supernatant of the oral fluid of patients were determined: The level of lipid peroxidation (LPO) in contance malondialdehyde (MDA) by reaction with thiobarbituric acid; Activity of the antioxidant enzyme catalase; The total proteolytic activity (OPA) kazeinolitic Kunitz method modification Levitsky A. P. Biochemical studies of oral liquids conducted on 77 people, 15 of whom were young people with intact peri-odontal (control group for biochemical studies), 26 patients and 36 patients with chronic catarrhal gingivitis and generalized periodontitis of the initial I -I and degree. Level of lipid peroxidation in the oral fluid was determined by the content of the end product of lipid peroxidation – MDA and antioxidant status system – on the activity of the antioxidant enzyme catalase. Lysozyme activity was judged by an oral liquid antimicrobial properties and state of nonspecific resistance in the oral cavity. Biochemical studies have shown that the patients with chronic catarrhal gingivitis and generalized periodontitis of the initial I -I degree and power extent compared with a group of individuals with intact periodontal Dont steam observed increase in MDA in oral liquids ty that indicates an increase in the intensity of lipid peroxidation in the at oxi-dation major components of cell membranes. This, in turn, activates the body’s antioxidant system, as evidenced by increased activity katalase in oral fluid. This fact characterizes the adequacy of compensation bottom atoms during the initial stages of inflammation in the oral cavity – patients with chronic catarrhal gingivitis and generalized periodontitis of the initial I -I degree. As a result of biochemical studies found violations of LPO – AOS and natural increase in the activity of inflammatory markers (acid phosphatase). On the basis of these studies was justified and algorithm of professional oral hygiene in patients with inflammatory periodontal diseases.

biochemicaloral fluid, chronic catarrhal gingivitis, generalized periodontitis

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