Dubinin S. I., Ryabushko O. B., Volobuev M. A., Ulanovska-Tsyba N. A.

Structural Features of the Predatory Fish Gallbladder

About the author:

Dubinin S. I., Ryabushko O. B., Volobuev M. A., Ulanovska-Tsyba N. A.



Type of article:

Scentific article


The structural features of the pike and sander gallbladder walls in comparative anatomical aspect have been studied. This work can help to solve the problems of prevention of gallstone diseases and effective treatment of inflammatory processes in the hepatobiliary system. The gallbladder’s bottom specimens of pike (Esox lucins) have shown much thicker wall. The inner wall membrane is well distinguishable from the surface. It is represented by thick fibrous structures that looks hypereosinophilic. Most of them have oblique and longitudinal direction relative to the gallbladder length. Typically these fibrous structures which are in close proximity to the basal membrane are forming a dense layer. A distance between the fibers is gradually increasing and intervals variable in form have appeared too. Sometimes they reach a relatively large size. Respecting gallbladder’s body it should be noted that its walls from the cavity side are sufficiently smooth. In some places the slight protrusion of the wall can be seen which is difficult to recognize as real folds of mucous mem-brane. The walls of this part of the gallbladder in longitudinal sections are histologically differ. The wall facing toward the liver is more thinner compared to the opposite wall. It consists of three layers. The inner layer facing toward the bladder cavity consists of a thin eosinophilic plate. It is a basal membrane. The widest layer formed by winding thin fibers in parallel to the previous layer is located next. Studying histological sections of the bottom gallbladder walls of the sander (Sander lucioperca) turns our at-tention to the varieties of the wall structure. The inner surface of the bottom wall often in convoluted shape. But it’s bulging does not much expressed. The single formed bulges covered by the basal membrane are located on the center of the bottom. They node-shaped with flat top and resemble to a sectioned pyramid. Loose clusters of hype-reosinophilic fibers are located under the basal membrane. Their directions correspond to the wall axis. Both wall, basically, consist of thin, densely packed convoluted fibers, generally resembles an elastic mem-brane. Loose structure is located on the opposite wall of the liver, outside of the elastic membrane. This structure forms a relatively thick layer which contains large areas of fat. Lipocytes in this area are different not only by size but also in shape. Oval-shaped lipocytes are connected to the previous membrane. Their long size is directed parallel to the elastic membrane. The elements of the microvascular bed are located among the fat cells. They are arterioles and venules which differ in wall structure and size by cross-sectional analyses. The small lymphatic vessels are lo-cated between the blood vessels mentioned above. The lymphatic trunks of different calibers are sometimes clearly visible along with these structural elements. In this case the presence of neurovascular bundles has discussed. The gall bladder wall facing toward the liver has more compact structure. The opposite or free wall of the gallbladder looks loose and resembles a sponge. In addition, a quite wide strip of loose connective tissue joins to the wall too. Part of this tissue contains a fat layer, elements of the hemomicrocircular bed and large number of small lymphatic vessels of different directions. In our point of view, such structure of the wall histostructures condi-tioned by the functional activity of all elements. Primarily, it is due to dehydration activity of the gallbladder content.


gall bladder, cystic duct, cholecystitis, cholelithiasis.


  • 1. Автандилов Г. Г. Медицинская морфометрия / Г. Г. Автандилов. – М.: Медицина, 1999. – 384 с.
  • 2. Аруин Л. И. Морфологическая диагностика болезней желудка и кишечника / Л. И. Аруин, Л. Л. Капуллер, В. А. Иса-ков. – М.: Триада-Х, 1998. – 456 с.
  • 3. Агаханян Н. Г. Изменения морфометрических параметров желчного пузыря человека в период инволюции / Н. Г. Ага-ханян // Морфология. – 2008. – №2. – С. 7.
  • 4. Афанасьев ю. И. Гистология / ю. И. Афанасьев, Н. А. юдина. – М.: Медицина, 1999. – С. 607-608.
  • 5. Агаханян Н. Г. Форма и объем желчного пузыря в инволютивный период онтогенеза человека по данным ультразвуко-вых исследований / Н. Г. Агаханян // Морфология. – 2009. – №4. – С. 8.
  • 6. Валькер Ф. И. Морфологические особенности развивающегося организма / Ф И. Валькер. – Л.: Медгиз, 1994. – 103 с. 7. Верин В. К. Желчный пузырь. Руководство по гистологии / В. К. Верин. – СПб.: СпецЛит, 2001. – Т. II. – С. 172-173.
  • 8. Волкова О. В. Эмбриогенез и возрастная гистология внутренних органов человека / О. В. Волкова, М. И. Пекарский.– М.: Медицина, 1996. – С. 155-157.
  • 9. Гертвиг О. О. Элементы эмбриологии человека и позвоночных животных: Для врачей и студентов. Пер. с нем. / О. Гертвиг. – СПб.: Изд. К. Л. Риккера, 1908. – 194 с.
  • 10. Дерижанова И. С. Об изменении клеточного состава эпителия желчного пузыря при холециститах / И. С. Дерижано-ва. – Ростов-на-Дону. – 2006. – Ч. 1. – С. 79-81.
  • 11. Дубінін С. І. Морфо-функціональна характеристика печінки, жовчного міхура та магістральних жовчовивідних проток у собак при експериментальному гострому холециститі в динаміці / С. І. Дубінін // Вісник морфології. – 1998. – №1 – С. 46-47.
  • 12. Крючков В. Н. Эколого-морфологические особенности патологии и адаптации органов и тканей рыб: дис. . . . доктора биол. наук: спец. 03. 00. 16 / Крючков В. Н. – Дагестанская Государственная Медицинская академия, ГБОУ ВПО. – Ма-хачкала, 2004. – 123 с.
  • 13. Мельгунов В. И. Анатомия, Морфология, Физиология Животных / В. И. Мельгунов// Избранные научные журналы. – 2002-2004.
  • 14. Сливка О. Я. Состав холатов желчи у больных холестерозом / О. Я. Сливка, А. Я. Фищенко // Лабораторное дело. – 2001. – №11. – С. 633-656.
  • 15. Albay S. Morphometry of the gallbladder during the fetal period / S. Albay, M. A. Malas, E. Koyuncu, E. H. Evcil // Surg. Radiol. Anat. – 2010. – Vol. 32(4). – P. 363-369.
  • 16. Ben Brahim E. Gastric heterotopia: clinical and histological study of 12 cases / E. Ben Brahim, R. Jouini, S. Aboulkacem [et al.] // Tunis Med. 2011. – Vol. 89(12). – P. 935-939.
  • 17. Karayiannakis A. J. Common bile duct obstruction secondary to a periampullary diverticulum / A. J. Karayiannakis, H. Bolanaki, N. Courcoutsakis // Case Rep Gastroenterol. – 2012. –Vol. 6(2). – P. 523-529.

Publication of the article:

«Bulletin of problems biology and medicine» Issue 2 part 3 (109), 2014 year, 109-113 pages, index UDK 611. 36+591. 436