Analysis of Hyper-Ige-Syndrome Prevalence among Practically Healthy Adolscent Individuals

Chopyak V. V., Zubchenko S. О., Pasichnyuk І. P.

CONTENTS

Scentific article

This work is dedicated to determine the prevalence of allergopathology and triggers of the formation of hyper-IgE-syndrome among practically healthy adolescent individuals. Written survey was conducted of 603 healthy students of the medical college aged 17-22 years regarding life- style, heredity, living conditions, addictions, nutrition, infectious and somatic diseases, as well as detailed data history including allergy, etc. based on the original questionnaire. General clinical research and analysis of surveys was carried out by doctors-immunologists and allergologists of the regional medical center of Clinical Immunology and Allergology. Quantitative determination of total serum IgE by ELISA was used for screening for allergy status. Based on the analysis of personal details and survey results it was found out, that allergic diseases were noted in 39. 13 % of the students. It was established that the main clinical manifestations of allergopathology were allergic rhinitis (40, 29 %) and dermatitis (32. 23 %). Semiotics of allergopathology responded with signs of relevant allergic disease. Age debut of allergic diseases in most cases was of 4, 4 1, 2 years. The most common causes of allergopathology in students were insect allergens, wholefood, cosmetics and chemicals. It was found out, that 43. 1% of individuals out of 603 students had an increased concentration of IgE. Also it was determined that high concentration of IgE was observed in 1. 2 times more frequently among graduate students compared to first-year students; students of urban residents (41. 2%) compared to rural youth (22,1%, p <0,01 ). Higher concentrations of IgE was found more frequently for 52. 2% in students whose parents had allergic disease, 49. 1% – in students who were on artificial feeding during the first year of their life. Among 42. 9% students – smokers it was identified the direct correlation between the number of cigarettes smoked a day and concentration of serum IgE (r = +0,84; p 0,01). It was proved that under the influence of frequent psycho-emotional stress factors IgE levels increased by an average of 1. 5 times, and in 16 (8. 1%) students was higher than 600 IU / ml. Comparative analysis of IgE level regarding features of ANS functioning showed that it was probability to increase of this immunoglobulin in students of constitutional dominance of vagotonic activity (44. 3%) compared with those in which sympatotonic activity and vegetative balance (respectively 40. 7% and 40,51%) were dominant. Among students with helminthiases high level of IgE was registered in 51. 6% of subjects, which was significantly (p <0, 01) more than in the group without helminthiases (36. 4%). Relative risk of developing of hyper-IgE syndrome was 41. 8% higher in students with helminthiases than in students without helminthiases. It was determined the probability of hyper-IgE syndrome and allergopathology the in students, who often suffered from acute respiratory viral infections and diseases of upper respiratory tract (56. 3%, p <0. 01), which could indicate the formation of acquired immunodeficiency.

allergopathology, practically healthy adolescent people, hyper-IgE-syndrom

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