LABORATORY FEATURES OF PNEUMONIA CAUSED BY ATYPICAL PATHOGENS, AS COMPARED TO THOSE WITH TUBERCULOSIS IN CHILDREN

Hakimova R. A., Mamarasulova D. Z., Maksumova D. C., Botirova B. T., Abdullaev M. B., Askarov I. S.

CLINICAL AND EXPERIMENTAL MEDICINE

Scentific article

Actuality: clinicians in outpatient and hospital very often became confronted with the problem of differential diagnosis of community-acquired pneumonia and tuberculosis in children. Especially in recent years, in the etiology of community-acquired pneumonia have become prevalent pneumonia caused by Mycoplasma pneumoniae and Chlamydophila (Chlamydia) pneumonia. Differential diagnosis of difficulty is also linked tems and that among children active tuberculosis, not confirmed by microbiological methods, found in 90.0% of cases among adolescents in the 50.0%-70.0% according to different authors. Chronically recurrent Chlamydia and Mycoplasma pneumonia is often reminiscent of the flow of tuberculosis, which is a cause for hospitalization in TB facilities. The aim of the study: was to examine differences in the clinical course of SARS tuberculosis, reveal pathognomonic symptoms and methods of investigation that allow to distinguish between the listed diseases in children. Materials and Methods: 67 patients were examined children referred to the regional TB hospital for diagnosis and treatment of tuberculosis. All the children in the history of repeated treatment for nonspecific pneumonia and received during the last month of antibiotic treatment of a wide spectrum of action, without radiographic positive changes. According to the patient after the traditional standard study Methods: ELISA (enzyme-linked immunosorbent assay) study was carried out "AT-TUBES-BEST Strip" (manufacturer - JSC "Vector-Best", similar strips for the determination of chlamydia and mycoplasma antigens and immunoglobulins, as well as indications We conducted an accelerated method for the detection of Mycobacterium tuberculosis and drug resistance by GeneXpert and sowing on nutrient medium at Bactec 960 machine. Research Results and Discussion. 51 patients this study has allowed to establish the diagnosis of tuberculosis, 16 patients excluded tuberculous process, of whom 9 patients detected chlamydia in 7 mycoplasma pneumonia. Careful study of the clinical course of disease revealed a peculiar symptom, allowing to suspect a particular disease. The diagnosis of tuberculosis in these patients excluded on the basis of history, clinical onset and course of the disease, the negative results of sputum microscopy method, plating on nutrient media and negative studies Gene Xpert, and crops on Bactec 960 machine. Conclusion. Thus, in children with chronic pneumonia in case of suspicion of tuberculosis should be carried out in addition to standard methods of research applied to the study of sputum GeneXpert machine and sowing on nutrient medium at Bactec 960 machine. IFA diagnosis with tuberculosis, Chlamydia and Mycoplasma antigens. The most characteristic symptom of Chlamydia and Mycoplasma pneumoniae are more acute onset of the disease, the higher the temperature, headache, hoarseness, rhinitis, arthralgia and myalgia, a rich percussion and auscultatory picture.

tuberculosis, diagnosis and differential diagnosis, immune ferment analysis with tuberculosis, chlamydia and mycoplasma antigens, detection Mycobacterium tuberculosis by Gene Xpert, crops on Bactec 960 machine

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«Bulletin of problems biology and medicine» Issue 1 part 2 (127), 2016 year, 124-127 pages, index UDK 616.24-002.5-07