Zaychenko G. V., Gorchakova N. O., Savchenko N. V., Klymenko O. V., Sorocopud K. Ju.


About the author:

Zaychenko G. V., Gorchakova N. O., Savchenko N. V., Klymenko O. V., Sorocopud K. Ju.



Type of article:

Scentific article


Cardio-vascular treatment and diagnostics is one of the main medicine problem all over the world. Although there are many drugs with proved effectivity for cardiovascular diseases treatment, the searching of the new possibilities for the better diagnostics and cure is continued. In the review it is shown physiological, pathophysiological and pharmacological ghrelin role in the function of cardiovascular system. Ghrelin is a multifunctional peptide hormone, mainly synthesized by P/D1cells of the stomach fundus mucosa. It was found in the pancreas, hypophysis, heart, kidney, lungs, placenta vessels. Its basic effect that is realized by GHS-R1-receptor in the arcuate and ventromedial nucleuses of hypothalamus is stimulation of the pituitary hormone synthesis. Ghrelin improves appetite, normalizes energy, carbohydrate, lipid metabolism, decreases cell proliferation and apoptosis. The first works were devoted to its ability for somatotropic hormone production intensification, appetite stimulation, leptin content lowering because leptine decreases the appetite. It is necessary for reproductive function. Later it was stated hat ghrelin improves memory, cognitive functions and teaching. It defences from depression and worry. Ghrelin increases dopamine- and cholinergic activity of CNS. Ghrelin has anabolic action, regulates growth and supports homeostasis. It oppresses fat utilization but causes hyperglycemia. Later it was shown that ghrelin oppresses cardiomyocetes apoptosis. Ghrelin has cardioprotective, vasodilator influence, takes part in the cardio- and systhrmic hemodynamics regulation. Ghrelin has antioxidant, antiapoptyc, anti-inflammatory, immunothropic action. It improves function and remodulation of the left heart ventricle in the case of cardiac insufficiency after injury of heart by ischemic-reperfusion mechanism. Cardioprotective ghrelin action is explained by decrease of cardiac rate, systolic pressure in the left ventricle, increase myocardial contraction and relaxation. Ghrelin inhibits the apoptosis of cardiomyocites and endothelial cells. Its vasodilator effect is connected with elevation the production of NO by stimulation of NO-synthase, lowering vasoconstrictor endothelin-1-level. Molecular mechanism of ghrelin action on vessels is consisted in signal way use. This effect is realized CHS-R-1a, phosphoinositide-3-kinase, alpha serin/treonin proteinkinase and endothelial synthetase (eNOS). Ghrelin lowers peripheral vascular resistance, stabilizers arterial pressure. It was investigated in the experiments that ghrelin decreases the symptoms of lung hypertension and defences the myocardium from arrythmyas appearance. There are some works that are shown the ghrelin effectivity as the biomarker in the cardiac insufficiency that is more exact comparately with troponine and sodium uretic peptide.


ghrelin, peptide hormone, regulatory action on cardio-vascular system, biomarker.


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Publication of the article:

«Bulletin of problems biology and medicine» Issue 1 (155), 2020 year, 39-44 pages, index UDK 616. 007. 21:612. 43/45. 018. 2+577:154. 365