SENSITIVITY EVALUATION OF CLINICAL STRAINS OF C. ALBICANS ISOLATED FROM PATIENTS WITH PHARYNGOMYCOSIS TO THE COMBINED EFFECT OF MONARDA ESSENTIAL OIL AND ANTIFUNGAL DRUGS

Zachepylo S. V.

MICROBIOLOGY

Scentific article

Abstract. The growing role of micromycetes in the development of opportunistic lesions of the ENT organs has led to the widespread use of a significant number of antifungal drugs. This, in turn, is inevitably accompanied by the formation of fungal resistance to antifungals. The use of antimicrobial compositions that contain drugs with different mechanisms of action is a priority course in finding new ways to overcome the threat of antifungal resistance. A promising direction in solving this problem is the use of essential oils, which are characterized by antimicrobial, antioxidant, antiviral, anti-inflammatory, immunomodulatory properties. The MIC of monarda tubular essential oil for the reference and clinical strains of C. albicans was determined, and the effectiveness of the combined action of monarda tubular essential oil with antifungal drugs of different chemical groups on the reference strain C. albicans ATCC 10231 and clinical strains of C. albicans patients with pharyngomycosis. The results of the study established a pronounced antifungal activity of the essential oil of monarda tubular on the reference strain of C. albicans ATCC 10231 and clinical isolates of C. albicans. However, the reference strain of C. albicans ATCC 10231 showed a higher sensitivity to the essential oil of monarda tubular and to the combined effect of the essential oil of monarda tubular with antifungal drugs of different chemical groups (nystatin and fluconazole) than clinical isolates of C. albicans. The data obtained in the study of the combined action of the essential oil of monarda tubular with nystatin and the essential oil of monarda tubular with fluconazole indicate a synergism of their antifungal effect against the reference strain of C. albicans ATCC 10231 and clinical isolates of C. albicans. The most effective was the combined effect of the essential oil of monarda tubular and fluconazole in relation to the reference strain of C. albicans ATCC 10231, and clinical isolates of C. albicans. The obtained data showed the prospects for further research on the development of new drugs.

essential oil of monarda tubular, pharyngomycosis, antifungal drugs, clinical isolates of C. albicans.

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«Bulletin of problems biology and medicine» Issue 1 (159), 2021 year, 184-188 pages, index UDK 579:616.322-002-078

10.29254/2077-4214-2021-1-159-184-188