GRAPHIC AND PLASTIC OESOPHAGEAL RECONSTRUCTION IN THE EARLY PERIOD OF HUMAN ONTOGENESIS

Antonyuk O. P, Vovk Yu. N, Marchuk O. F, Marchuk F. D.

MORPHOLOGY

Scentific article

Abstract. During the embryonic period, intensive processes of mutual influence occur between the rudiments of the esophagus, trachea, lungs and heart. The rudiment of the esophagus increases in size, and protrusions of the organ are formed both in the anterior and sagittal planes. The process of formation of the mucous membrane of the esophagus begins, as well as the fusion of the rudiments of the diaphragm, close topographic and anatomical relationships with the vagus nerves are established. The beginning of the pre-fetal period of development is marked by the process of delimiting the esophagus from the trachea, which leads to the formation of a pronounced compaction of mesenchymal cells around the rudiments of the mucous membrane of the separated organs. The formation of the topographic-anatomical relationship of the esophagus at this stage of intrauterine development is quite dynamic and is in closely connection with the intensive development of the heart, large vessels of the mediastinum and lungs. The study of graphic and plastic reconstructions and histological preparations showed that blood vessels grow into the submucous layer of the esophagus during the 7th week of development; in the middle part of the esophageal rudiment (at the level of the trachea bifurcation), there is a pronounced narrowing, which should be considered the beginning of the formation of the broncho-aortic narrowing of the esophagus in the prefetal period of development, the process of delimiting the esophagus from the trachea occurs, which leads to the formation of a pronounced compaction of mesenchymal cells around the rudiments of the mucous membrane of the divided organs; further there is an active process of transformation of the epithelium of the mucous membrane of the esophagus – from a two-layer cylindrical (prefetus 60.0-65.0 mm parietal-coccygeal length – 11th week) to a four-layer cylindrical (prefetus 70.0-75.0 mm parietal-coccygeal length – 12th week) epithelium.

embryogenesis, esophagus, graphic and plastic reconstruction.

1. Cerri PS, de Faria FP, Villa RG, Katchburian E. Light microscopy and computer three-dimensional reconstruction of the blood capillaries of the enamel organ of rat molar tooth germs. Journal of Anatomy. 2004;204(3):191-195. doi: 10.1111/j.0021-8782.2004.00268.
2.  Werner H, Lopez J, Tonni G, Araujo E. Plastic reconstruction of fetal anatomy using three-dimensional ultrasound and magnetic resonance imaging scan data in a giant cervical teratoma. Med Ultrason. 2015;17(2):252-5. doi: 10.11152/mu.2013.2066.172.tert.
3. Kosmaidou-Aravidou Z, Siabalioti G, Karpathios S, Grigori P, Panani A. Prenatal diagnosis of a cervical teratoma with a cytogenetic study. J Matern Fetal Neonatal Med. 2006;19(6):377-9. doi: 10.1080/14767050600647621.
4. Schievano S, Sebire NJ, Robertson NJ, Taylor AM, Thayyil S. Reconstruction of fetal and infant anatomy using rapid prototyping of postmortem MR images. Insights Imaging. 2010;1:281-6. doi: 10.1007/s13244-010-0028-5.
5. Lee CF, Chen PR, Lee WJ, Chen JH, Liu TC. Computer Aided Three-Dimensional Reconstruction and Modeling of Middle Ear Biomechanics By High-Resolution Computed Tomography and Finite Element Analysis. Biomedical Engineering Applications Basis and Communications. 2006;18:214-221. doi: 10.4015/S1016237206000348.
6. Akhtemiychuk YuT, Oliynyk IYu. Kliniko-morfolohichni aspekty doslidzhen velykykh slynnykh zaloz. Klinichna anatomiya ta operatyvna khirurhiya. 2009;8(3):76-80. [in Ukrainian].
7. Oleynik IYu. Sposob izgotovleniya plastin dlya rekonstruktsii s tselyu ikh primeneniya v rekonstrutsiyniy morfologii. Klinicheskaya i eksperimental’naya patologiya. 2004;3(4):95-96. [in Russian].
8. Turkevich NG. Rekonstruktsiya mikrosokpicheskikh obyektov po gistologicheskim srezam. M: Meditsina; 1967. 176 s. [in Ukrainian].
9. Krutsyak VN, Akhtemiychuk YuT, Vataman VN. Graficheskiye i plastichesk rekonstruktsii v izuchenii razvitiya i stanovleniya topografii organov v prenatal’nom periode ontogeneza cheloveka. Mat-ly konferentsii. Embriogenez i sravnit. anatomia organov i sistem. 1986. Minsk; s. 18-23. [in Russian].
10. Akhtemiychuk YuT. Organogenez zabryushinnogo prostranstva. Chernivtsi: Prut; 1997. 148 s. [in Russian].
11. Bilash SM, Pronina OM, Koptev MM. Comprehensive morphological studies as an intergal part of modern medical science. Literature review. Visnyk problem biolohiyi i medytsyny. 2019;2.2(151):20-3. DOI: 10.29254/2077-4214-2019-2-2-151-20-23

«Bulletin of problems biology and medicine» Issue 1 (159), 2021 year, 193-197 pages, index UDK 611.32.013

10.29254/2077-4214-2021-1-159-193-197