TREATMENT EFFECT ON QUALITY OF LIFE AND PSYCHOEMOTIONAL STATUS IN PATIENTS WITH CHRONIC PANCREATITIS

Потяженко М. М., Китура О. Е., Невойт А. В., Настрога Т. В., Люлька Н. А.

CLINICAL AND EXPERIMENTAL MEDICINE

Scentific article

Currently, the tendency for the increase in the incidence of chronic pancreatitis (CP) both in Ukraine and in the world can be observed. Prolonged course of CP causes deterioration in the quality of life (QOL) and leads to the various changes in psychoemotional state of patients. The aim of the study is to assess QOL and anxiety level in patients with CP under the treatment effect. Object and methods of research.The study involved 68 CP patients, including 36 women and 32 men. The average age was 56.9 ± 7.4 years, the duration of the disease was 9.5 ± 4.9 years. The research included evaluation of pain syndrome severity (according to a visual analogue scale), quality of life (by specialized questionnaire for gastroenterological patient GSRS) and the anxiety disorders level (using Ch.D. Spilberger-Yu.L. Khanin questionnaire) at the initial stage of treatment and after three weeks of treatment. Results and their discussion. According to the pain syndrome intensity in patients with CP based on VAS scale, four clinical groups were identified: group I – 10 (14.7%) patients who did not experience pain, group II – 12 (17.6%) patients with weak pain, group III – 36 (52.9%) patients evaluating pain as moderate, and IV clinical group – 10 (14.7%) patients experiencing severe abdominal pain. The analysis of QOL in each clinical group has determined the significant QOL deterioration in groups III and IV caused by pain and dyspeptic syndromes severity and in groups I and II due to diarrheal and dyspeptic syndromes. When assessing the “obstipation syndrome” and “dyspeptic syndrome” scales, the significant differences between clinical groups were not observed. After three weeks of therapy, the improvement in QOL of all the patients according to “reflux syndrome”, “diarrhea syndrome” and “dyspeptic syndrome” scales was observed. The positive dynamics was observed in clinical groups with mild and severe pain syndrome according to “abdominal pain” scale. The significant differences between clinical groups and on the background of treatment were not observed according to “obstipation syndrome” scale. According to Ch.D. Spilberger-Yu.L. Khanin questionnaire data the general group of patients with CP presented with a high level of RA – 3.25 ± 0.67 points and PA level was up to high and amounted to 2.95 ± 0.29 points. Carrying out a detailed analysis of clinical groups, a very high level of RA was observed in IV group patients, high level of RA – in I and III groups and the average RA level −in II group. The decrease in clinical symptoms severity on the background of performed treatment has caused RA decrease in the general group of CP patients up to 1.58 ± 0.48 points (p<0,05), PA level did not change significantly and amounted to 2.9 ± 0.32 points. The decrease in the level of reactive anxiety was observed in all clinical groups. Dynamic changes in PA level on the background of treatment were not revealed in all clinical groups. Conclusions 1. Patients with CP experienced QOL deterioration caused by severity of pain, dyspeptic and diarrheal syndromes and significant changes in the psychoemotional status in the form of increased level of personal and reactive anxiety. 2. The more pronounced QOL deterioration and very high RA could be observed in patients with severe pain and diarrheal syndromes. 3. The improvement in QOL and the decrease in the level of RA were observed on the background of CP treatment during three weeks.

chronic pancreatitis, quality of life, level of anxiety

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«Bulletin of problems biology and medicine» Issue 1 Part 1 (142), 2018 year, 163-167 pages, index UDK 616.37-002-08:616.89

10.29254/2077-4214-2018-1-1-142-163-167