FEATURES OF HORMONAL HOMEOSTASIS IN WOMEN WITH EARLY MENOPAUSE

Сhayka K. V., Shalko M. N., Stepanenko T. O., Zahorodnya O. S.

CLINICAL AND EXPERIMENTAL MEDICINE

Scentific article

Preterm menopause is not a very popular condition, but the consequences of it are significant not only for reproductive health, but also for somatic and psychological wellbeing. The article presents the results of the study of the concentration of the main female reproductive hormones in women with different age of termination of menstrual function. The goal of the study was to investigate the peculiarities of hormonal homeostasis by preterm ovarian insufficiency. Hormonal status of 74 women with menopause, that happened before 40 years old, was compared with these of 70 women with menopause after 45 years and 70 women with saved menstrual function. In the vast majority of menopause women of up to 40 years have critically low serum estradiol concentrations. This distinguishes them from a group of men with menopause after 45 years, one third of which had a concentration of estradiol at the lower limit of the reference values. In addition, in women with early menopause, for 18 months after the last menstruation, the alignment of the ratio of estrone/estradiol is evident, indicating a deeper depletion of the follicular apparatus. It means, that women with preterm menopause are considered to stay in deeper estrogen deficit. The low concentration of antimullerian hormone proves the origin of early amenorrhea, not associated with ovarian resistance syndrome. Despite the same changes in the concentration of FSH and inhibin B in menopausal women, only a group of patients with early ovarian exhaustion revealed a correlation between these parameters, which proves the differences in the origin of menopause until 40 years and after 45 years. It confirms the popular idea about dominating role of inhibine insufficiency in preterm menopause. The obtained data prove that women whose menstrual function has ended up to 40 years, are in a deeper estrogen deficiency.

early menopause, FSH, estradiol, estrone, inhibin B, antimullerian hormone

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«Bulletin of problems biology and medicine» Issue 1 Part 1 (148), 2019 year, 199-202 pages, index UDK 618.17-008.8-008.64-039.11:577.17

10.29254/2077-4214-2019-1-1-148-199-202