Halperin O. I., Rudenko K. A., Pridyus I. O., Kaplunenko A. M., Frolova G. M.

SIGNIFICANCE OF MICROELEMENTS CERIUM AND GERMANIUM FOR SUPPORT OF THE MORPHO-FUNCTIONAL STATUS OF THE ORGANISM


About the author:

Halperin O. I., Rudenko K. A., Pridyus I. O., Kaplunenko A. M., Frolova G. M.

Heading:

LITERATURE REVIEWS

Type of article:

Scentific article

Annotation:

Biotechnological preparations, which include microelements, which according to the results of researches of many scientists carry out a number of vital functions in the body, are quite promising. Among the problems developed in modern morphology of the fundamental and applied nature, the attention of researchers is attracted by the study of the laws of the course of basic processes of morphogenesis and organogenesis under the influence of trace elements. Cerium and its compounds are an important trace element for the body and modern studies on the influence of this metal and its nanofocus on the body are conducted quite actively. It has been experimentally determined that the unique property of cerium dioxide nanoparticles is the ability to regenerate their restorative properties in a biological environment. Of particular interest is the use of cerium dioxide as a prophylactic in the treatment of radiotherapy for cancer, which protects against radiation damage, reduces the production of free forms of oxygen and increases the expression of superoxide dismutase. Studies have shown that the proliferation and growth of stem cells on the substrate containing the CeO2 nanoparticles was much better than to the non-filled or to the substrate containing any other oxide filler. Its specific physical and chemical properties allow to optimize the nature of the flow of intracellular reactions, thus providing a range of protective effects. The data obtained in mice provided additional evidence of the positive effect of cerium nanoparticles, in nanoparticles of cerium in old mice, protecting ovarian cells from oxidative damage, which results in an increase in the quantitative rates of litter in old calf mice. Administration of calcium in old males at a dose of 1 mg/kg over a period of 10 days greatly increases the level of testosterone, the quantity of sperm and the number of calves in the inflorescence. In vitro cardiac fibroblasts incubation with 100 nM cerium leads to an increase in the synthesis of RNA, but the rate of DNA synthesis does not change. However, researchers note that higher concentrations of cerium in the environment had an inhibitory effect. An analysis of experimental results has shown that cerium at low levels can act at the transcription level to stimulate the synthesis of collagen and protein, which, in turn, can contribute to the accumulation of collagen in endocardial fibrosis. Introduction of germanium citrate to female rats 30 days before fertilization and during pregnancy and lactation induces leads to multiple fertility, increased viability and the amount of survived rodents compared to control. It is proved that germanium possesses immunostimulant, antioxidant, antihypertensive, anti-inflammatory and analgesic properties. Analysis of scientific published data showed that cerium and germanium are important for the organism as trace elements, and the study of the influence of these metals on the body is carried out quite actively and, undoubtedly, is a promising area of research in biology and medicine. However, the information on the influence of cerium and germanium compounds on embryogenesis and cardiogenesis and their interaction in an organism with compounds of heavy metals remains unclear in the scientific world literature.

Tags:

cerium, cerium dioxide, germanium mikroelements, embryogenesis.

Bibliography:

  1. Borysevych VB, Kaplunenko VH, Kosinov MV. Nanomaterialy v biolohiyi. Osnovy nanoveterynariyi. K.: VD “Avitsena”; 2010. 416 s. [in Ukrainian].
  2. Kaplunenko VH, Avdos“yeva IK, Pashchenko AH. Realʹni perspektyvy vykorystannya zdobutkiv nanotekhnolohiy u veterynarniy praktytsi. Naukovo-tekhnichnyy byuletenʹ Instytutu biolohiyi tvaryn i Derzhavnoho naukovo-doslidnoho kontrolʹnoho instytutu vetpreparativ ta kormovykh dobavok. 2014;4:252-60. [in Ukrainian].
  3.  Shatorna VF, Haretsʹ VI, Nefʹodova OO, Kaplunenko VH, Chekman IS. Rolʹ nanochastok tsytrativ metaliv u poshuku novykh bioantohonistiv yembriotoksychnosti atsetatu svyntsyu [monohrafiya]. Dnipropetrovsʹk: Serednyak T.K.; 2016. 118 s. [in Ukrainian].
  4.  Shatorna VF, Haretsʹ VI, Nefʹodova OO. Eksperymentalʹne vyznachennya kombinovanoho vplyvu atsetatu svyntsyu ta tsytratu sribla na kardiohenez shchuriv. Ukrayinsʹkyy zhurnal medytsyny, biolohiyi ta sportu. 2016;2:293-7. [in Ukrainian].
  5.  Hardas SS, Butterfield DA, Sultana R. Brain distribution and toxicological evaluation of a systemically delivered engineered nanoscale ceria. Toxicol. Sci. 2010. 65 p.
  6. Karakoti AS, Monteiro Riviere NA, Aggarwal R. Nanoceria as antioxidant: synthesis and biomedical applications. JOM J. Miner. Met. Mater. Soc. 2008;60(3):33-7.
  7. Sugaya K, Seal S, inventor. Methods and materials for stimulating proliferation of stem cell. United States patent 2008/0166412 A1 A61K9/16; A61K35/12; A61K33/24; C12N5/02. 07.10.2008.
  8.  Tarnuzzer RW, Colon J, Patil S, Seal S. Vacancy engineered ceria nanostructures for protection from radiation induced cellular damage. Nano Lett. 2005;5(12):2573-7.
  9. Mandoli C, Pagliari F, Pagliari S. Stem cell aligned growth induced by CeO2 nanoparticles in PLGA Scaffolds with improved bioactivity for regenerative medicine. Adv. Funct. Mater. 2010;20:1617-24.
  10.  Ivanov VK, Shcherbakov AB, Usatenko AV. Strukturnochuvstvitel’nyye svoystva i biomeditsinskiye primeneniya nanodispersnogo dioksida tseriya. Uspekhi khimii. 2009;78(9):924-41. [in Russian].
  11. Spivak NYa, Nosenko ND, Zholobak NM, Shcherbakov AB, Reznikov AG, Ivanova OS, i dr. Nanokristallicheskiy dioksid tseriya povyshayet funktsional’nuyu aktivnost’ reproduktivnoy sistemy stareyushchikh samtsov krys. Nanosistemy: fizika, khimiya, matematika. 2013;4(1):72-7. [in Russian].
  12.  Shcherbakov AB, Zholobak NM, Ivanov VK, Tret’yakov YuD, Spivak NYa. Nanomaterialy na osnove dioksida tseriya: svoystva i perspektivy ispol’zovaniya v biologii i meditsine. Bіotekhnologіya. 2011;4(1):9-24. [in Russian].
  13.  Spivak NYa, Shepel EA. Ceria nanoparticles boost activity of aged murine oocytes. Nano Biomed Eng. 2012;4:183-8.
  14.  Kumar, Prakash, D’Souza, Sunita Shivakumar, Rathinam. Cerium stimulates protein biosynthesis in rat heart in vivo. Biological trace element research. 1996;50:237-42.
  15. Prakash Kumar, Shivakumar Km. Alterations in collagen metabolism and increased fibroproliferation in the heart in cerium-treated rats: Implications for the pathogenesis of endomyocardial fibrosis. Biological trace element research. 1998;63:73-9.
  16.  Ambrosov IV, Aleshin SV, Alimbarova LM, Matelo SK, Shokhin IYe. Ispol’zovaniye organicheskikh soyedineniy germaniya v meditsine. Razrabotka i registratsiya lekarstvennykh sredstv. 2015;2(1):144-50. [in Russian].
  17.  Asai K. Miracle Cure: Organic Germanium. 1980; New York: Japan Publications. 139 р.
  18.  Voynar AI. Biologicheskaya rol’ mikroelementov v organizme zhivotnykh i cheloveka. M.: Vyssh. shk.; 1960. 498 s. [in Russian].
  19. Gromova OA, Rebrov VG. Vitaminy, makro- i mikroelementy. M.: Gêotar-media; 2008. 954 s. [in Russian].
  20.  Kaplunenko VH, Avdos“yeva IK, Pashchenko AH. Realʹni perspektyvy vykorystannya zdobutkiv nanotekhnolohiy u veterynarniy praktytsi. Naukovo-tekhnichnyy byuletenʹ Instytutu biolohiyi tvaryn i Derzhavnoho naukovo-doslidnoho kontrolʹnoho instytutu vetpreparativ ta kormovykh dobavok. 2014;15(4):252-60. [in Ukrainian].
  21. Fedoruk RS, Khrabko MÍ. Dinamíka masi tíla í reproduktivna funktsíya samok shchurív ta zhittêzdatníst’ priplodu za vipoyuvannya ríznikh kíl’kostey tsitratu germaníyu. Bíologíya tvarin. 2015;17(3):214-6. [in Ukrainian].
  22. Nischemenko NP, Trokoz VO, Poroshynska OA, Stovbecka LS, Emelynenko AV, Emelynenko AA. The influence of nanoaquachelates of selenium, germanium and their complex on the embryonic development of quails. Fiziol. Zh. 2018;64(3):30-6.
  23.  Fedoruk RS, Khrabko MÍ. Dinamíka masi tíla í reproduktivna funktsíya samok shchurív ta zhittêzdatníst’ priplodu za vipoyuvannya ríznikh kíl’kostey tsitratu germaníyu. Bíologíya tvarin. 2015;17(3):214-6. [in Ukrainian].
  24.  Fedoruk RS, Khrabko MÍ, Dolaychuk OP. Vpliv tsitratu germaníyu na ímunofízíologíchnu aktivníst’ organízmu shchurív. Fízíol. zhurn. 2017;63(2):65-9. [in Ukrainian].
  25.  Seba MV, Sheremeta VÍ, Khomenko MO. Bíokhímíchní pokazniki kroví korív pri zastosuvanní preparatu «Kvatronan-Se» ta karboksilatív kharchovikh kislot. Naukoviy vísnik Natsíonal’nogo uníversitetu bíoresursív í prirodo-koristuvannya Ukraíni. Seríya «Tekhnologíya virobnitstva ̈ í pererobki produktsíí̈ tvarinnitstva». 2016;236:268-76. [in Ukrainian].
  26.  Seba MV, Deyneka MO (Khomenko MO), Kaplunenko VG. Vpliv preparatu «Kvatronan-Se» ta deyakikh míkroyelementív u formí karboksilatív na zaplídneníst’ ta molochnu produktivníst’ korív simental’s’koí̈ porodi. Naukovo-tekhníchniy byuleten’ naukovo-doslídnogo tsentru bíobezpeki ta yekologíchnogo kontrolyu APK. 2016;4(1):234-40. [in Ukrainian].
  27.  Seba MV, Khomenko MO. Gormonal’ní zmíni v organízmí telits’ píslya zastosuvannya novogo preparatu ta kompleksív nanokarboksilatív. Tvarinnitstvo Ukraíni. 2017;3-4:17-20. [in Ukrainian].

Publication of the article:

«Bulletin of problems biology and medicine» Issue 1 Part 2 (149), 2019 year, 24-29 pages, index UDK 611.12-076:611.013:616-092.9:669.018.674

DOI: