STRUCTURAL-FUNCTIONAL FEATURES OF SALIVARY GLANDS OF MIXED SECRETION

Yeroshenko G. A., Shevchenko K. V., Kramarenko D. R., Bilash S. M., Pronina О. M., Yachmin A. I.

LITERATURE REVIEWS

Scentific article

The article presents modern views on the structural and functional features of salivary glands of mixed secretion, according to the data of domestic and foreign literature. In the cavity of the mouth open the excretory ducts of the three pairs of salivary glands: the parotid, submandibular and sublingual, lying outside of the oral mucosa. They consist of the end-pieces and ducts. The structure was analyzed in the age aspect of the submandibular and sublingual salivary glands: the study of changes in morphological characteristics of the submandibular salivary glands of human fetus showed that features in the fetal period of prenatal ontogenesis are manifestations of the genetic (hereditary) ability of the individual to the formation of additional and independent lobules of the gland. The peculiarity of the morphological characteristics of the sublingual human’s salivary gland in the fetal period of prenatal ontogenesis is the genetic ability to form independent additional lobules of the gland having independent excretory ducts. Mergence of secretory end-pieces of independent lobules of the sublingual glands with the main component of the germ of the gland is observed at the end of the pre-fetal period – the beginning of the fetal periods of prenatal ontogenesis. With age, thickening of the wall and narrowing of the lumen occur, a significant increase in the Vogenvord’s index, small caliber arteries, which leads to worsening vascular throughput, inadequate blood supply to the organ, damage to the endothelial cells, and endothelial dysfunction. Observations of age-related changes in human salivary glands indicate almost double the increase in the specific number of connective and adipose tissue in the older age group compared with the group at 17-21 years, with almost three times the decrease in the number of evacuation ducts in the older age group in all glands. The submandibular and sublingual hypertrophy of the salivary glands refer to the glands of mixed secretion. The secretion of salivary glands is saliva, which is characterized by a high level of metabolism associated with energy-intensive processes of synthesis and secretion of saliva. The secretory function is provided with sympathetic and parasympathetic innervation, hormonal effects, local regulatory substances and constant interaction of glandulocytes with the blood supply system. Consequently, saliva not only participates in processes that pass through the oral cavity, which gives us the notion of the importance of these glands in maintaining the homeostasis of the oral cavity. but also a highly informative object reflecting the general health of a person.

salivary glands, mixed secretion, age aspect.

1. Yousem DM, Kraut MA, Chalian AA. Major salivary gland imaging. Radiology. 2000;216(1):19-29.
2. Tsukanov DV. Strukturni osoblyvosti pryvushnykh slynnykh zaloz shchuriv pislya vvedennya platyfilinu. Svit medytsyny ta biolohiyi. 2012;4:120- 2. [in Ukrainian].
3.  Afanasyev YuI, Yurina NA, redaktory. Gistologiya, embriologiya, tsitologiya: uchebnik; 6-ye izd., pererab. i dop. Moskva: GEOTAR-Media; 2012. 798 s. [in Russian].
4.  Paches AI, Tabolinovskaya TD. Opukholi slyunnykh zhelez. Moskva: Prakticheskaya meditsina; 2009. 470 s. [in Russian].
5.  Shevchenko KV, Yeroshenko HA, Kramarenko RD, Pronina OM, Kudinov MV. Suchasni uyavlennya pro strukturno-funktsionalnu orhanizatsiyu slynnykh zaloz. Visnyk problem biolohiyi i medytsyny. 2018;3(145):50-8. [in Ukrainian].
6. Yeroshenko GA. Strukturna orhanizatsiya velykykh slynnykh zaloz za umov stymulyatsiyi sympatychnoho ta parasympatychnoho viddiliv vehetatyvnoyi nervovoyi systemy [avtoreferat]. Simferopol; 2010. s. 7-28. [in Ukrainian].
7. Koveshnikov VH, redaktor. Anatomiya lyudyny: v 3-kh t.; pidruchnyk dlya stud. VMNZ. Tom 2. Luhansk: Virtualna realnist; 2007. 259 s. [in Ukrainian].
8.  Lutsyk OD, Chaykovskyi YuB, redaktory. Histolohiya. Tsytolohiya. Embriolohiya: pidruchnyk. Vinnytsya: Nova knyha; 2018. s. 445-7. [in Ukrainian].
9. Lutsyk OD. Histolohiya lyudyny: pidruch. dlya studentiv VMNZ. Vyd. 4-te dooprats. i vypr. Kyiv: Knyha plyus; 2010. 584 s. [in Ukrainian].
10. Opravin AS, Ulyanovskaya SA, Afonicheva YeN. Organometricheskiye kharakteristiki podnizhnechelyustnykh slyunnykh zhelez cheloveka v plodnom periode ontogeneza v Arkhangelskoy oblasti. Mezhdunarodnyy zhurnal prikladnykh i fundamentalnykh issledovaniy. 2014;1:255. [in Russian].
11. Tabachnyuk NV, Oliynyk IYu. Zmina morfolohichnykh ta antropometrychnykh kharakterystyk pidnyzhnyoshchelepnykh slynnykh zaloz plodiv lyudyny. Visnyk problem biolohiyi i medytsyny. 2014;1,4(113):296-301. [in Ukrainian].
12.  Tabachnyuk NV, Oliynyk IYu. Morfohenez pidnyzhnyoshchelepnoyi slynnoyi zalozy v zarodkiv i peredplodiv lyudyny. Aktual. probl. suchasn. med.: Visn. Ukr. med. stomat. akad. 2014;14(3):258-61. [in Ukrainian].
13.  Bernik NV. Morfolohichna ta antropometrychna kharakterystyka pidyazykovykh slynnykh zaloz u plodovomu periodi prenatalnoho ontohenezu lyudyny. Klinichna anatomiya ta operatyvna khirurhiya. 2014;13(3):48-53. [in Ukrainian].
14. Kuvayeva OV, Vasilyeva LS. Struktura podchelyustnoy zhelezy cheloveka i yeye polovyye osobennosti v pervyy period zrelogo vozrasta. Uspekhi sovremennogo yestestvoznaniya. 2009;3:43. [in Russian].
15. Hnatyuk MS, Posolenyk LYa. Strukturno-funktsionalne doslidzhennya osoblyvostey vikovoyi perebudovy arteriy pidnyzhnyoshchelepnoyi zalozy. Medychna khimiya. 2013;15(2):48-51. [in Ukrainian].
16.  Kulayeva LV, Burov VV, Semina MN. K voprosu o vozrastnykh izmeneniyakh slyunnykh zhelez cheloveka [Internet]. Byulleten meditsinskikh internet-konferentsiy. 2013;3(2) [tsitirovano 7 fevr. 2015]. Dostupno: http://medconfer.com/node/1928 [in Russian].
17. Denisov AB. Slyuna i slyunnyye zhelezy. Izd. 2-ye,pererab. i dop. Moskva: Izd-vo RAMN; 2009. 470 s. [in Russian].
18.  Pronina OМ, Koptev MM, Bilash SМ, Yeroshenko GA. Response of hemomicrocirculatory bed of internal organs on various external factors exposure based on the morphological research data. Svіt medicini ta bіologіі. 2018;1(63):153-7.
19. Hnatyuk MS, Hasyuk PA. Histokhimichna kharakterystyka struktury atsynarnoho viddilu velykykh slynnykh zaloz lyudyny. Medychna khimiya. 2012;14(1):118-20. [in Ukrainian].
20.  Yeroshenko GA. Zminy tynktorialnykh vlastyvostey tsytoplazmy epiteliotsytiv slynnykh zaloz pislya vvedennya adrenalinu i atsetylkholinu. Svit medytsyny ta biolohiyi. 2013;1(36):122-4. [in Ukrainian].
21. Gerasimova YeYe. Uroven oksida azota i antiradikalnaya aktivnost v sekretakh bolshikh slyunnykh zhelez (khronobiologicheskiy aspekt). Elektronnyy nauchno-obrazovatelnyi vestnik «Zdorovye i obrazovaniye v XXI veke». 2010;12(3):140-1. [in Russian].
22.  Kovalenko OV, Yeroshenko GA, Kostenko VO. Morfofunktsionalni zminy pidnyzhnyoshchelepnoyi slynnoyi zalozy shchuriv za umov khronichnoho travmatychnoho sialadenitu ta vvedennya l-selenometioninu. Svit medytsyny ta biolohiyi. 2012;1(32):112-6. [in Ukrainian].
23. Aure MH, Konieszny SF, Ovitt CE. Salivary gland homeostasis is maintained through acinar cell self-duplication. Developmental Cell. 2015;33(2):231-7.
24. Timofeyev AA. Sekretornaya funktsiya slyunnykh zhelez u bolnykh s ostrymi odontogennymi vospalitelnymi zabolevaniyami chelyustey. Sovremennaya stomatologiya. 2011;4:70-4. [in Russian].
25. Tsukanov DV. Strukturne zabezpechennya slynoutvorennya v normi. Aktual. probl. suchasn. med.: Visn. Ukr. med. stomat. akad. 2014;14(2):200- 4. [in Ukrainian].
26.  Tymoshenko YuV. Morfo-funktsionalni osoblyvosti slyzovoyi obolonky tverdoho pidnebinnya za umov eksperymentalnoyi kserostomiyi [avtoreferat]. Dnipro; 2018. s. 6-14. [in Ukrainian].
27.  Lin AL, Johnson DA, Stephan KT, Yeh C-K. Alteration in Salivary Function in Early HIV Infection. Journal of Dental Research. 2003;82(9):719-24.
28.  Senchakovych YuV, Yeroshenko HA, Kazakova KS. Suchasni pohlyady na prychyny dysfunktsiyi slynnykh zaloz. Svit medytsyny ta biolohiyi. 2013;4(41):112-6. [in Ukrainian].
29. Yeroshenko GA, Yashchenko AM, Koptеv MM, Shevchenko KV. Osoblivostі citotopografіі plazmocitіv u velikih slinnih zalozah shchurіv u normі ta pri rіvznih funkcіonal’nih stanah. Svіt medicini ta bіologіі. 2017;4(62):179-82. [in Ukrainian].
30.  Chaykovskyi YuB, Tsukanov DV. Strukturni osoblyvosti pid nyzhnyoshchelepnykh slynnykh zaloz shchuriv pislya vvedennya prozerynu. Svit medytsyny ta biolohiyi. 2012;2:172-5. [in Ukrainian].
31.  Yeroshenko GA, Shepitko VI, Chaykovskyi YuB. Slynni zalozy. Histofiziolohiya stymulyovanoyi sekretsiyi. Poltava: UMSA; 2014. 149 s. [in Ukrainian].
32. Yeroshenko GA. Analiz znachushchosti korelyatsiynykh zvyazkiv mizh morfometrychnymy pokaznykamy pidyazykovykh slynnykh zaloz shchuriv pislya stymulyatsiyi. Visnyk problem biolohiyi i medytsyny. 2012;2(3):160-3. [in Ukrainian].

«Bulletin of problems biology and medicine» Issue 1 Part 2 (149), 2019 year, 30-34 pages, index UDK 616.316-07

10.29254/2077-4214-2019-1-2-149-30-34