APPLICATION OF TINCNURE FROM LEMNA MINOR FROND, L-THYROXIN AND THEIR COMBINATION FOR THE CORRECTION OF THE HYPOTYROID STATE IN RATS

Kononenko A. G., Kravchenko V. M.

CLINICAL AND EXPERIMENTAL MEDICINE

Scentific article

To treat hypothyroid conditions mainly use hormone replacement therapy, which causes side effects and often leads to hormone-resistance. However, there was a need to find alternative methods for compensation of hypothyroid state, one of which is herbal preparations. The aim. Study of the efficiency of 30% tincture from Lemna minor frond and its combination with L-thyroxin in experimental hypothyroidism. Object and methods. Experimental hypothyroidism induced by daily administration of mercazolilum solution instead of drinking water for 30 days. Hypothyroid animals received orally tincture from Lemna minor frond, L-thyroxin and its combination. After experiment blood collected, thyroid gland isolated and weighed in rats. Concentrations of T3 , fT3 , fT4 and T4 estimated in blood serum samples. Results. It established that the weight of the thyroid gland in rats treated with tincture from Lemna minor frond decreased in 2.6 times (p <0.05), in rats treated with L-thyroxin – decreased in 1.9 times (p <0.05). Combination of tincture from Lemna minor frond with L-thyroxin led to a decreasing of thyroid weight in 2.5 times (p <0.05) compared with a CP group. Introduction of tincture from Lemna minor frond contributed to significant increase of T4 , fT4 , fT3 and T3 in 2.4, 2.7, 1.6 and 1.9 times (p <0.05), respectively, compared with a CP group. Administration of L-thyroxin led to the likely increase of T4 , fT4 , fT3 and T3 compared to the CP group in 1.9, 1.9, 1.50 and 1.9 times (p <0.05), respectively. Combination of investigated objects increased levels of T4 , fT4 , fT3 and T3 in 2.4, 3.1, 1.8 and 1.9 times compared to the animals of CP group. Conclusions. The administration of tincture from Lemna minor frond and L-thyroxin benefit a corrective effect on the thyroid gland hypofunction, and introduction of their combination led to their effect potentiation.

tincture from Lemna minor frond, experimental hypothyroidism, mercazolilum, thyroid hormones, L-thyroxin.

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«Bulletin of problems biology and medicine» Issue 1 Part 2 (149), 2019 year, 152-155 pages, index UDK 615.322:615.357:615.451.16:616.441

10.29254/2077-4214-2019-1-2-149-152-155