ANTIFUNGAL AGENTS IN TERMS OF ACQUIRED RESISTANCE IN CANDIDA SPECIES
About the author:
Iungin O. S.
Type of article:
As long as in Ukraine and all over the world Candida spp. causes dangerous mycosis in immunosuppressive patients new drugs and targets for antifungal treatment needs to be found. In this review it is analysed available antifungal agents used to treat diseases caused by Candida spp. including resistant to azoles drugs C. albicans and non-albicans species. It was also estimated the ratio of C. albicans and non-albicans species in causing hospital infections. It was shown the ability of hospital C. albicans and non-albicans species to form biofilms as well. Different classes of drugs are described by the targets of their action focused on cell compartments. Among them are echinocandins, polyenes antibiotics, pyrimidines etc. These groups have been shown as the most effective against azole-resistant Candida strains. Also, the phenomenon of biofilm formation in the pathogenesis of mycoses were described as well as new targets for antifungal drugs associated with the formation of biofilms: quorum-sensing molecules, exopolymer matrix, eDNA. These new targets are the promising way for resistant species treatment. The effective way to combat hard infection is to combine antibiofilm and antifungal treatment to make described drugs work. Particular attention is focused on drugs that can suppress the formation of biofilms. Antimicrobial compounds binding with DNA/RNA used as new anti-biofilm drugs. The most effective representatives of this group are diamidines and flucytosine. Fungal quorum-sensing molecules (farnesol and tirosol) could be the potential targets for drug development as these molecules were described as virulent agents and coordinates yeast-host relations. As another effective approach to improve the tactics of antifungal treatment, a comprehensive use of drugs with a synergistic mechanism of action is considered.
antifungal agents, biofilm, C. albicans, resistance
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Publication of the article:
«Bulletin of problems biology and medicine» Issue 2 (144), 2018 year, 83-86 pages, index UDK 579.6