FREQUENCY COMPATIBILITY CARDIOVASCULAR DISEASES WITH BENIGN PROSTATIC HYPERPLASIA THE PROSTATE GLAND IN MEN DIFFERENT AGE GROUP

Jafarova Z. I.

CLINICAL AND EXPERIMENTAL MEDICINE

Scentific article

Purpose. Study of the structure and frequency of cardiovascular diseases in patients with BPH. Methods. A total of 200 men aged 50 to 79 years were examined. The average age of the examined patients was 65.3±0.5 years. Taking into account the significant age fluctuations of the Central hemodynamics and cardiovascular system, three age groups of patients were taken under observation: 50-59, 60-69 and 70-79 years. In the first age group, i.e. in the age range of 50-59 years, there were 64 males, in the II subgroup – 70 and III age group (70-79 years) there were 66 males. All patients were examined according to the standard program recommended by who to identify cardiovascular diseases. The diagnosis was established on the basis of complaints, anamnesis, the presence of electrocardiographic (ECG), echocardiographic (EchoCG) signs. Results. We have conducted two series of studies. The first series of follow-up was conducted by studying the frequency and structure of cardiovascular diseases in patients with BPH according to the data of circulation within a year from the moment of diagnosis of BPH. The control group for this series were men who did not suffer from BPH. The second series of observations was carried out by direct study of patients with BPH and the control group by studying the frequency of cardiovascular diseases during hospitalization in the urological clinic. To determine the prevalence of individual forms of coronary heart disease, hypertension and risk factors in patients with BPH, we examined 200 patients with BPH and 200 persons without this pathology. In patients with BPH in all age groups clearly observed increase in the frequency of coronary artery disease. Thus, in patients in the III age group (70-79 years), the incidence of coronary artery disease exceeded this indicator in the I and II age group, respectively, in 3.8 (p<0.01) and 2.0 times (p<0.05). In relation to the incidence of GB significant difference was not observed. Comparative analysis with the control indicators showed that IHD and GB in patients aged 50-59 years compared with men in the control group of the same age group were found, respectively, in 2.2 (p<0.05) and 1.7 (p<0.05) times more often, in patients aged 60-69 years – 1.5 (p<0.05) and 1.7 times (p<0.05) and in patients aged 70-79 years – 1.6 (p<0.05) and 1.4 times respectively. According to the results of the study, the frequency of IHD as a whole was 35.0%, while GB – 16.1 %. Also, the highest rate in the structure of other cardiovascular diseases was revealed in relation to NS. In this case, IHD was more often diagnosed in the III age group, both in frequency and in structure. Conclusion. The combination of NS and BPH is due to the common role of the age factor in the occurrence of these pathologies. AG exacerbates the risk of both pathologies and increases the likelihood of their combination. Our study confirmed that although hypertension and BPH are two different diseases, they may have a common pathophysiological mechanism of development with age.

benign prostatic hyperplasia (BPH), unstable angina (NS), AH

1. Zejnalov AF, Gumbatov NB, Ismajlova SS. Rasprostranennost’ faktorov riska v neorganizovannoj populjacii muzhchin 20-59 let g. Baku. Aktual’nye voprosy kardiologii. Sborn. statej. Baku, 1988. s. 77-81. [in Russiаn].
2. Imamverdiev SB, Azizov VA, Orudzheva RI, Gadimaliev FG. Adenomjektomija predstatel’noj zhelezy u bol’nyh s soputstvujushhej ishemicheskoj bolezn’ju serdca. Azerb. med. zhurnal. 1988;7:43-6. [in Russiаn].
3. Ismailova NR, Kuliev FA, Zejnalov AF, Faradzheva NA, Gadzhieva GG. Vzaimosvjaz’ arterial’noj gipertenzii s ishemicheskoj bolezn’ju serdca v muzhskoj populjacii v gornom rajone Azerbajdzhana (po dannym populjacionno-jepidemiologicheskogo issledovanija). Materialy III Mezhdunar. Kongressa «Arterial’naja gipertenzija – ot Korotkova do nashih dnej». 21-23 maja 2015. S-Peterburg. Arterial’naja gipertenzija. 2015;t.21, prilozhenie. s. 82-3. [in Russiаn].
4. Mathur RP, Nayak S, Sivaramakrishnan R, Jain V. Role of Alpha Blockers in Hypertension with Benign Prostatic Hyperplasia. Journal of the association of physicians of India. 2014;62:40-4.
5. Repin AN, Sergienko TN, Karpov PG. Lechenie arterial’noj gipertenzii u pozhilyh bol’nyh. Sistemnye gipertenzii. 2007;2:54-61. [in Russiаn].
6. Di Cesare M, Bennett JE, Best N, Stevens GA, Danaei G, Ezzati M. The contributions of risk factor trends to cardiometabolic mortality decline in 26 industrialized countries. Int J Epidemiol. 2013;7:45-8.

«Bulletin of problems biology and medicine» Issue 2 (144), 2018 year, 161-164 pages, index UDK 616.65-007.61-08

10.29254/2077-4214-2018-2-144-161-164