FEATURES OF THE INFLAMMATORY PERIODONTAL DISEASE IN METABOLIC SYNDROME

Abduvakilov Zh. U., Rizaev Zh. A.

DENTISTRY

Scentific article

The problem of modern dentistry today is the problem of the effect of systemic disorders, characteristic of the metabolic syndrome, on the organs and tissues of the oral cavity. The reason for this is the relationship between systemic factors and the degree of severity of the disease, since in the pathogenesis of pathological processes in periodontal tissues, microcirculatory, metabolic, enzymatic and immunological disorders are of great importance. A serious medical and social problem is the metabolic syndrome, whose prevalence according to WHO in industrialized countries is 10-20% in the population over the age of 30, and 25% in the United States. Metabolic syndrome is characterized by the presence of the patient’s tissue insulin resistance, hyperinsulinemia, impaired glucose tolerance, primary arterial hypertension, dyslipidemia and hyperlipidemia, as well as abdominal obesity, microalbuminuria and hyperuricemia. Such diseases as diabetes mellitus, arterial hypertension and lipid metabolism disorders, which refer to the components of the concept metabolic syndrome, can influence the progression of periodontal diseases to a greater extent than periodontal pathogens. The purpose of this study was to study the characteristics of carbohydrate and lipid metabolism, as well as indicators of the total immunity in peripheral venous blood in patients with chronic generalized periodontitis (CGP) of moderate severity against the background of metabolic syndrome. A comprehensive examination of 58 patients with chronic generalized periodontitis of moderate severity aged 35 to 63 years, as well as 14 volunteers (practically healthy people) with intact periodontitis aged 25-35 years who made up a control group (CG) was performed. It is shown that in patients with MS combined with inflammation in periodontal tissues against the background of hyperinsulinemia and dyslipidemia, pronounced changes in the indices of cellular and humoral immunity are observed. It was found that the increase in IgG in the blood on the background of a decrease in Ig A, which is probably due to the enhanced synthesis of secretory IgA.

parodontium, chronic generalized periodontitis, metabolic syndrome, carbohydrate and lipid metabolism

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«Bulletin of problems biology and medicine» Issue 2 (144), 2018 year, 353-355 pages, index UDK 616.314.-002-073.584-053.3

10.29254/2077-4214-2018-2-144-353-355