Ivashchuk Yu. V


About the author:

Ivashchuk Yu. V



Type of article:

Scentific article


Recent years have shown that patients with rheumatoid arthritis (RA) have a higher risk of cardiovascular complications and mortality. Rheumatoid arthritis is a common and severe chronic inflammatory joint disease, the frequency of which in the population ranges from 0.5 to 1.0%. It is one of the most widespread autoimmune diseases in the world leading to early disability, and therefore the need to improve the approaches to clinical management of such patients is obvious. The most common comorbid conditions among RA patients are hypertension (HT). At present, it remains an open-ended question to study the diagnosis of comorbid cardiovascular conditions in patients with rheumatoid arthritis for the purpose of drug correction of dyslipidemia. The aim of the study. To determine the peculiarities of diurnal profile of AP, blood lipid spectrum in patients with HT in combination with RA and to evaluate the effectiveness of using average doses of rosuvastatin to correct dyslipidemia in this group of patients. Results. Changes in indicators of the diurnal artery pressure profile, detected in most patients with hypertension in combination with rheumatoid arthritis, were characterized by increased average daytime, average night time levels of systolic AP, increased daytime variability and a lower degree of nocturnal decrease in comparison with patients without RA. Most of the patients examined had increased triglycerides, low-density lipoprotein cholesterol, total cholesterol – 17 (40.48%), 24 (57.14%) and 21 (50%) patients, respectively, and 18 (42,86%) patients had decreased high-density lipoprotein cholesterol. The use of 20 mg of rosuvastatin as part of complex therapy in patients with HT in combination with RA contributed to the achievement of target indicator levels of lipid spectrum in blood of most patients.


hypertension, rheumatoid arthritis, circadian blood pressure profile, blood lipid profile, rosuvastatin, lipoproteins, circadian blood pressure profile.


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Publication of the article:

«Bulletin of problems biology and medicine» Issue 2 (156), 2020 year, 103-107 pages, index UDK 616.12-008.331.1+616.72-002.77:616.13-0046]-08