SUBSTANTIATION OF THE COMPLEX APPROACH IN THE EVALUATION OF HEALING EFFECT OF MINERAL NATURAL TABLE WATER

Gushcha S. G., Nasibullin B. A., Nikipelova E. M., Tikhokhod L. V., Saltaniuk V. N.

HYGIENE AND ECOLOGY

Scentific article

The use of mineral waters (MW) ensures that the complex of macro- and microelements in the body in their most active form enters the body and subsequently participates in the realization of their biological action. Due to the presence of these components in MV, they are able to exert a regulating influence on the activity of many functional systems of the body. One of the possible effects of the action of MW is to increase the functional reserves of the body, known as the “healing effect”. The latter is more characteristic of MW canteens, which can be used for a long time (almost daily in the form of refreshing drinks). It is believed that the MW canteens in their chemical composition are not a large load for the body, in contrast to the medical canteens and medicinal MW, which are recommended to be used under the supervision of a physician, in order to avoid negative consequences. According to EU directives, the biological activity of MW is evaluated either by changes in a single homeostasis indicator, or by analogy of the chemical composition of the MW. At the same time, our experience shows that a more adequate task is a comprehensive assessment of the state of the main functional systems of the body under the influence of mineral waters. Based on the foregoing, the purpose of the work is to substantiate the “healing effect” of the natural dining room of MW based on a comprehensive assessment of the state of the functional systems of the body of white rats with different uses. The material of the work was the data obtained using white female rats weighing 180-200 grams, divided into three groups. The first – 16 intact rats served as a control (comparison group). The second – 17 rats, which in the form received MW “Obolonskaya” for 30 days in the mode of free access to this MW. The third group – 17 rats who received for 30 days, once a day this MW method of intragastric administration (intragastric) in an amount of 1% of body weight. The solstation of the functional activity of the CNS was assessed; it was estimated that the functional state of the kidneys was assessed; change in a number of metabolic parameters; state of peripheral blood and immediate response; structural and functional changes in the internal organs (liver, kidney, heart, stomach). Animals received packaged mineral natural table water, which by its chemical composition is slightly mineralized bicarbonate, magnesium-calcium sodium, the total mineralization is 0.50 g/l. The results of a comprehensive assessment showed that the nature and focus of homeostasis indicators do not depend on the options for using MW. Differences are observed in the quantitative characteristic of changes in individual indicators. According to the results of morphological studies, it can be argued that damage to the parenchyma of the internal organs of the MW does not cause. There are signs of increased function of the gastrointestinal tract in its intra-gastric administration. An assessment of the functional activity of the central nervous system revealed a calming effect of applied MW, more pronounced in the free water regime. In the urinary system, MW increases glomerular filtration rate and increases the excretion of potassium ions and chloride ions, and contributes to the retention of sodium ions. On the part of the metabolism indicators, there is a decrease in the intensity of detoxification processes in the liver while simultaneously intensifying bile formation and biliary excretion. On the part of peripheral blood, the use of MW did not cause changes. On the part of the immune response, a slight weakening of the activity of the cellular component was observed, while it was unchanged from stronons humoral. Thus, a comprehensive assessment of the impact of natural table MW showed that the response to its action involves the functional systems of the organism of the rat, which allows us to consider it as a nonspecific modulator. In addition, changes in the activity of the central nervous system, urinary and detoxification systems suggest that MW can cause a “healing effect”.

mineral water, complex assessment, functional systems of the body.

1. Lebedeva TL, Gozhenko YeA. O fiziologicheskoy prioritetnosti sistemy osmoregulyatsii pri upotreblenii pit”yevykh i mineral’nykh vod. XÍI–ye chteniya VV. Podvysotskogo: Byulleten’ materialov nauchnoy konferentsii. Odessa: UkrNII meditsiny transporta; 2013. s. 56-7. [in Russiаn].
2. Zayko NN, Bytsya YuV, redaktory. Patologicheskaya fiziologiya. M.: MEDpress-inform; 2006. 640 s. [in Russiаn].
3. Zaychik ASh, Churilov LP. Osnovy obshchey patologii. Chast’ 2. Osnovy patokhimii. SPb: ELBI; 2000. 688 s. [in Russiаn].
4. Zolotareva TA, Babov KD, Nasibullin BA, Kozjavkin VI, Torohtin AM, Jushkovskaja OG. Medicinskaja reabilitacija. K.: KІM; 2012. 496 s. [in Russiаn].
5. Quattrini S, Pampaloni B, Brandi ML. Natural mineral waters: chemical characteristics and health effects. Clin Cases Miner Bone Metab. 2016;13(3):173-80.
6. Kolesnik EO, Babov KD. Mineral’nі vodi Ukrayni. K.: Kuprіjanova; 2005. 560 s. [in Ukrainian].
7. Pavlova YeS, Bakholdina YeI, Batsko YeS. Vliyaniye mineral’nykh vod razlichnogo makrosostava i soderzhaniya biologicheski aktivnykh veshchestv na nespetsificheskiye mekhanizmy formirovaniya adaptatsionnykh protsessov Meditsinskaya reabilitatsiya, kurortologiya, fizioterapiya. 2008;3:19-22. [in Russiаn].
8. Gushcha SG, Nasibullin BA, Krokos AA, Mohylevsʹka TV. Zminy pokaznykiv imunnoyi systemy zdorovykh shchuriv pid vplyvom slabkomineralizovanykh mineralʹnykh vod z pidvyshchenym vmistom orhanichnykh rechovyn. XVI–e chtenyya VV. Podvysotskoho: Byulletenʹ materyalov nauchnoy konferentsyy. Odessa: UkrNYY medytsyny transporta; 2017. s. 107-9. [in Ukrainian].
9. Loboda MV, Kyrtych LP, redaktory. Mineralʹni vody Zakarpattya. Pytne likuvalʹne vykorystannya. Uzhhorod: IVA; 1997. 174 s. [in Ukrainian].
10. Natochin YuV, redaktor. Vander A. Fiziologiya pochek: per. s angl. SPb.: Piter; 2000. 526 s. [in Russiаn].
11. Natochin YuV, redaktor. Sheyman DA. Patofiziologiya pochki. Per. s ang. LZ. Pevznera. M.: BINOM Spb; 2002. 206 s. [in Russiаn].
12. Reilly RF, Ellison DN. Distal Tubule: Physiology, Pathophysiology and Molecular Anatomy. Physiol. Rev. 2000;80(1):277-313.
13. Feraille E, Doucet А. Sodium-рotassium аdenosinetriphosphatase dependent sodium transport in the kidney: hormonal control. Physiol. Rev. 2001;81:345-418.
14. Ayus JC, Arieff AI. Glycine-induced hypo-osmolar hyponatremia. Arch Intern Med. 1997;157(2):223-6.
15. Gozhenko AI, Shumilova PA, Dolomatov SI. Vliyaniye osmoticheskikh nagruzok na funktsional’noye sostoyaniye pochek zdorovykh lyudey. Nefrologiya. 2004;8(2):44-8. [in Russiаn].
16. Shvets VI. Vzayemozv`yazok rehulyatsiyi vodno-solʹovoho obminu i hemostazu. Medychna hidrolohiya ta reabilitatsiya. 2006;4(1):66-9. [in Ukrainian].
17. Gushcha SG, Nasibullin BA, Trubka IА, Volyanskaya VS, Kalinichenko NV, Balashova IV. Comprehensive assessment of functional changes in the organism of healthy rats in external and internal use of silicone malomineralized mineral water. European Journal of Clinical and Biomedical Sciences. 2018;4(1):1-5.
18. Albertini МС, Dachа M. Drinking mineral waters: biochemical effects and health implications – the state of the art. Int. J. Environmental Health. 2007;1(1):153-69.
19. Babov KD, Zolotarova TA, Nasibullin BA, Nikipelova YeM, Pavlova YeS, Alekseyenko NA. Osobennosti biologicheskogo deystviya mineral’nykh vod raznoy mineralizatsii. K.: KIM; 2009. 60 s. [in Russiаn].
20. Andriyashek YuI. Vozmozhnyye novyye podkhody k vyboru i naznacheniyu pit’yevykh mineral’nykh vod. Vestnik fizioterapii i kurortologii. 2003;2:20-1. [in Russiаn].
21. Mikhnenko OI. Konkretyzatsiya sutnosti ponyattya “zdorovʹya” yak metodolohichne pidhruntya praktyky ozdorovlennya orhanizmu lyudyny. Pedahohika, psykholohiya ta medyko-biolohichni problemy fizychnoho vykhovannya i sportu. 2013;2:42-6. [in Ukrainian].
22. Ivanov DD. Mineral’nyye vody Yevropy: fokus na Italiyu. Pochki. 2015;2(12):15-8. [in Russiаn].
23. Azoulay A, Garzon P, Eisenberg MJ. Comparison of the mineral content of tap water and bottled waters. J Gen Intern Med. 2001;16(3):168-75.
24. Alekseyenko NA, Gushcha SG, Khmelevskaya ON, Solodova LB, Oleshko AYa. Mediko-biologicheskaya otsenka mineral’noy prirodnoy stolovoy vody skvazhiny № 2-B g. Kokshetau, respublika Kazakhstan, na etape doklinicheskikh issledovaniy. Medichna reabílítatsíya, kurortologíya, fízíoterapíya. 2014;2(74):43-5. [in Russiаn].
25.  Aleksyeyenko NА, Nasibullin BA, Gushcha SG. Osoblyvosti biolohichnoho vplyvu mineralʹnoyi likuvalʹno-stolovoyi vody «Rohatynsʹka» na orhanizm shchuriv. Medychna reabilitatsiya, kurortolohiya, fizioterapiya. 2013;1(73):30-2. [in Ukrainian].
26. Gushcha SG. Vplyv sulʹfidnoyi mineralʹnoyi vody na fiziolohichni, metabolichni ta morfolohichni kharakterystyky zdorovykh shchuriv. Voda: hihiyena ta ekolohiya. 2014;1-4(2):43-50. [in Ukrainian].
27. Nikipelova OM, Gushcha SG, Kysylevsʹka AYu, Nikolyenko SI, Zakharchenko YeA. Eksperymentalʹni peredumovy praktychnoho vykorystannya malomineralizovanoyi hidrokarbonatnoyi khlorydnoyi natriyevoyi vody sverdlovyny № 1 m. Kobelyaky Poltavsʹkoyi oblasti. Voda: hihiyena ta ekolohiya. 2016;1-2(5):68-80. [in Ukrainian].
28. Nakaz MOZ Ukrayni vіd 28.09.2009 r. № 692 «Pro zatverdzhennja metodichnih rekomendacіj z metodіv doslіdzhen’ bіologіchnoi dіi prirodnih lіkuval’nih resursіv ta preformovanih lіkuval’nih zasobіv». [in Ukrainian].
29. Instruction 2010/63/EU of European Parliament and Council on animals used for research and other purposes protection. Official Journal. 2010;276:33-79.
30. Nakaz Mіnіsterstva osvіti і nauki, molodі ta sportu Ukraуni vіd 01.03.2012 № 249 «Pro zatverdzhennja Porjadku provedennja naukovimi ustanovami doslіdіv, eksperimentіv na tvarinah». [in Ukrainian].
31.  Alekseyenko NA, Gushcha SG, Bondar’ IV, Ivanova AV, Yaroshenko NA. Vliyaniye mineral’noy vody «Sofiya Kiyevskaya» na funktsional’noye sostoyaniye pochek eksperimentral’nykh zhivotnykh pri raznykh sposobakh yeye vvedeniya v organizm. Medichna reabílítatsíya, kurortologíya, fízíoterapíya. 2011;2(66):25-7. [in Russiаn].

«Bulletin of problems biology and medicine» Issue 2 Part 1 (150), 2019 year, 83-88 pages, index UDK 615.327.076.9

10.29254/2077-4214-2019-2-1-150-83-88