MORBIDITY RATE OF THE SALIVARY GLANDS TUMOURS AND ITS DEPENDENCE ON HARMFUL EMISSIONS IN THE ATMOSPHERE BY ENTERPRISES IN THE SUMY AND CHERNIHIV REGIONS

Diachenko O. O., Kuzenko E. V., Shershneva E. S., Shako D. I., Kravtsova I. A.

HYGIENE AND ECOLOGY

Scentific article

Salivary gland tumours make up 3-5% of all the tumours of head and neck. The known factors that lead to onсological transformation of salivary gland cells are: smoking, ionizing radiation, the influence of viral agents (especially the Epstein-Barr virus), harmful working conditions at the production of nickel alloys and rubber; also the influence of alimentary factors and genetic mutations is under consideration. Salivary gland tumours can occur in patients of different ages. There are cases of detection of hemangiomas and sarcoma of parotid salivary glands in newborns. Tumours of salivary glands in elderly people are described. However, after the age of 70 tumours of this localization are rare. Studies from different regions of the world have demonstrated difference in frequency of tumour types, age and gender structure. Taking into account the regional variation of affection by salivary gland tumours a logical question appears about the prevalence and risk factors in different regions of Ukraine. Therefore, the purpose of our study is to analyze the incidence of salivary gland tumours in the northern regions of Ukraine (Sumy and Chernihiv regions) and to compare the obtained data with the ecological situation. The article presents the results of a statistical analysis of the incidence of salivary gland tumours in male and female population in the northern regions of Ukraine (Sumy and Chernihiv regions), analyzed data from the National Cancer Registry of Ukraine and environmental passports of Sumy and Chernihiv regions for the period from 2005 to 2016. The obtained data were compared with the number and types of harmful emissions into the atmosphere by environmentally hazardous facilities that are located in these regions. The conclusions on the results and prospects for further research are given.

salivary gland tumours, statistical analysis, Sumy region, Chernihiv region, harmful emissions into the atmosphere

1. Malanchyk VA, Kopchak AV. Dobrokachestvennyye opukholi i opukholepodobnyye porazheniya chelyustno-litsevoy oblasti i shei. К., 2008. 271 s. [in Russian].
2. Saku T, Hayashi Y, Takahara O. Salivary gland tumors among atomic bomb survivors, 1950-1987. Cancer. 1997 Apr 15;79(8):1465-75.
3. Chen AA, Gheit T, Stellin M. Oncogenic DNA viruses found in salivary gland tumors. Oral Oncol. 2017 Dec;75:106-10.
4. Svetitskiy PV, Zlatnik EU, Zykova TA, Nistratov GP, Ayedinova IV, Volkova VL, et al. Techeniye raka organov polosti rta s uchetom assotsiirovanosti s virusom Epshteynna-barr, papillomy cheloveka i urovnya nekotorykh tsitokinov. International journal of applied and fundamental research. 2014;11:120-2. [in Russian].
5. Horn-Ross PL, Ljung BM, Morrow M. Environmental factors and the risk of salivary gland cancer. Epidemiology. 1997 Jul;8(4):414-9.
6. Timofeyev AA. Rukovodstvo po chelyustno-litsevoy khirurgii i khirurgicheskoy stomatologii. Kiyev: 2002. s. 639-68. [in Russian].
7. Tykholiz IS. Ridkisnyy rak pidshchelepnoyi slynnoyi zalozy. Ukr. radiolohichnyy zhurn. 2009;17:182-5. [in Ukrainian].
8. Tian Z, Li L, Wang L, Hu Y, Li J. Salivary gland neoplasms in oral and maxillofacial regions: a 23-year retrospective study of 6982 cases in an eastern Chinese population. Int J Oral Maxillofac Surg. 2010 Mar;39(3):235-42.
9. WHO 2017: New Classification of Head and Neck Tumours.
10. Jatin P. Shah, Snehal G. Patel, Alice Y. Chen Cancer of the Head and Neck (Acs Atlas of Clinical Oncology). 2001.
11. Thomas KM, Hutt MS, Borgstein J. Salivary gland tumors in Malawi. Cancer. 1980 Nov 15;46(10):2328-34.
12. Zacharie Sando, Jean Valentin Fokouo, Arlette Onomo Mebada. Epidemiological and histopathological patterns of salivary gland tumors in Cameroon. The Pan African Medical Journal. 2016;23:66.
13.  Fonseca FP, Carvalho Mde V, de Almeida OP. Clinicopathologic analysis of 493 cases of salivary gland tumors in a Southern Brazilian population. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 Aug;114(2):230-9.
14.  Sokolova NA. Analiz zakhvoryuvanosti ta stan diahnostyky zloyakisnykh novoutvoren. Lik. sprava-Vracheb. delo. 2013;8:137-41. [in Ukrainian].
15. Margaret R. Spitz, MD, MPH, Barbara C. Tilley, PHD, John G. Batsakis, MD, Joanne M. Gibeau, MPH, Guy R. Newell, MD. Risk Factors for Major Salivary Gland Carcinoma. A Case-Comparison Study. Cancer. 1984;54:1854-9.

«Bulletin of problems biology and medicine» Issue 2 Part 1 (150), 2019 year, 89-92 pages, index UDK 616-006.699

10.29254/2077-4214-2019-2-1-150-89-92