Kozakevich O. B., Kozakevich V. K., Demidenkova G. G., Martynenko N. V., Kashchenko A. Y.


About the author:

Kozakevich O. B., Kozakevich V. K., Demidenkova G. G., Martynenko N. V., Kashchenko A. Y.



Type of article:

Scentific article


Improvement in obstetric and neonatal care contributed to a significant reduction in the mortality rate of premature babies, but increased the percentage of children with cognitive impairment. Therefore, it is especially important to identify in time the manner of the risk groups of violations of psycho-emotional development in a given cohort of children for early intervention in order to avoid the formation of disability in the future. Aim: to establish the clinical and genetic determinants of the formation of delayed psycho-emotional development in infants with very low and extremely low birth weight and to develop a prediction algorithm for this condition. Object and methods of research. A cohort prospective study was conducted, which included 155 infants with very low and extremely low birth weight. Their psycho-emotional development in 6, 12, 18, 24 and 36 months of life was studied and determinants determined. In accordance to the Order of the Ministry of Health of Ukraine dated March 20, 2008 No. 149 “Clinical protocol for medical care for a healthy child under the age of 3 years”. The study was carried out in accordance to the standards of bioethics. The material for genetic study was peripheral venous blood. A molecular genetic study was conducted using polymerase chain reaction techniques. Forecasting of the delay of psycho-emotional development was carried out with the help of simple and stepwise multiple logistic regression analysis. Results. In the 24 months of the corrected age 19% of children have psycho-emotional retardation, and in 36 months – almost 15% of children born with very low and extremely low body weight. Forcasting model for delayed psycho-emotional development in early age for children born with low and extremely low body weight is devised. Contributing factors to the psycho-emotional development of these determinants were demographic characteristics, socio-economic status of the family, peculiarities of antenatal and intranatal periods, the state of the child immediately after birth and the volume of primary reanimation, diagnoses, and volumes of treatment at the inpatient and non-stationary stages. Four reliable predictors of psycho-emotional development delay were revealed: severe VSK, body weight at discharge from a neonatal hospital less than 3 percentiles, artificial feeding at the discharge, and socio-economic status of the family, namely the upbringing of a child in an incomplete family.To find out the role of genetic determinants in delaying the psycho-emotional development of the examined children, we studied the association between the polymorphism of the genes of the glutathione-S-transferase family, dominant models of ACE genes; AGT2R1, e NOS and delayed psycho-emotional development in the examined children in 24 months of life. None of the genetic models studied GSTT1, GSTM1, GSTR1, ACE, AGT2R1 and eNOS genes were associated with a violation of the psycho-emotional development of infants born with body weight less than 1500 g. The model of prediction of early psycho-emotional development delay in children with very low and extremely low body weight at birth has been developed by our model has a moderate sensitivity (37.04%) and high specificity (92.86%). Conclusions. The high specificity of the developed model of prediction of delayed psycho-emotional development in prematurely born children indicates the possibility of its application in practical medicine. Our further research will focus on identifying specific candidate genes that are involved in the development of psycho-emotional development disorders in a larger cohort of prematurely born children with very low and extremely low body weight to prove the role of genetic mechanisms in the development of extremely premature infants


forecasting, psycho-emotional development, very low body weight, extremely low body weight, premature children.


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Publication of the article:

«Bulletin of problems biology and medicine» Issue 2 Part 1 (150), 2019 year, 139-144 pages, index UDK 616.89-008-053.32