EFFECT OF COMPLEX APPLICATION OF THIOTRIAZOLINE AND L-LYSINE ESCINATE ON MARKERS OF ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH NONALCOHOLIC LIVER DISEASE

Pivtorak K. V., Shevchuk N. A., Pivtorak N. A.

CLINICAL AND EXPERIMENTAL MEDICINE

Scentific article

The purpose of the study – to evaluate the efficacy, safety of thiotriazolin and L-lysine escinate using and to determine the effect of complex therapy on endothelial function parameters in patients with NAFLD. Object and methods. 135 patients with overweight and obesity were examined. Among them, 46 were overweight (BMI-25-29.9 kg/m2 ), 34 were obesity grade I (BMI-30-34.9 kg/m2 ), and 20 were obese, II grade (BMI-35-39.9 kg/m2 ). 35 patients had normal body mass (BMI 18-24.9 kg/m2 ). We also examined 20 practically healthy persons. All patients were divided into three groups. Patients of the first group received basic therapy (n = 50), in accordance with recommendations of the European Association for the Study of the liver, the European Association for the Study of Diabetes, the European Association for the Study of Obesity. Patients in the second group (n = 60) were assigned baseline therapy and thiotriazoline. Patients in the third group (n = 25), together with baseline treatment and thiotriazoline, were prescribed L-lysine escinate. All subjects were assigned the level of C-reactive protein, endothelin (ET-1) immunoassay using the “hsCRP ELISA” (“DRG” USA) and “Endothelin-1” (“DRG” USA). The activity the Villebrand factor (vWF) was determined by the immune enzyme method used by the company “Shield diagnostics”, Great Britain. The statistical analysis of the obtained results was carried out using the STATISTICA 8 program of Statsoft Company using parametric and nonparametric methods for evaluating the obtained results. Results and discussion. The additional use of thiotriazolin and L-lysine escinate significantly contributed to the concentration of ET-1. The level of ET-1 decreased in patients with NAFLD with normal body mass in 1,5 times, with overweight – in 1,4 times, with obesity I degree – in 1,5 times, with obesity II degree – in 1,6 times (p <0.05) compared with the period before treatment. The level of ET-1 decreased in patients with NAFLD with a normal weight of 20.9%, with overweight – by 16.3%, with obesity 1 degree – by 15.2%, with obesity II degree – by 21.1% (p <0.05) compared with baseline therapy. The concentration of C-reactive protein and von Willebrand factor factor also decreased statistically significantly. Conclusions. Combined therapy of patients with NAFLD by thiotriazolin and L-lysine escinate is an effective way to eliminate endothelial dysfunction, as evidenced by a decreasing the markers of endothelial dysfunction: endothelin-1, Villebrand factor and an inflammatory response marker – C-reactive protein

nonalcoholic fatty liver disease, endothelial dysfunction, treatment, thiotriazolin, L-lysine escinate.

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«Bulletin of problems biology and medicine» Issue 2 Part 1 (150), 2019 year, 176-181 pages, index UDK 616.36-003.826-092:616.175.8

10.29254/2077-4214-2019-2-1-150-176-181