CORRECTION OF INJURIES OF THE MUSCULOSKELETAL SYSTEM IN PATIENTS WITH SJOGREN’S SYNDROME USING AMARANTH OIL

Yakimenko D. O.

CLINICAL AND EXPERIMENTAL MEDICINE

Scentific article

The clinical picture of Sjogren’s syndrome is various and includes manifestations of lesions of the exocrine glands, signs of nonspecific activation of the immune system (weakness, subfebrile condition, myalgia, arthralgia, arthritis of the joints of the hands and knees), organ-specific autoimmune pathology (autoimmune thyroiditis, hepatitis, sclerosing cholangitis, autoimmune hemolytic anemia). The peculiarities of the lesion of the joints in the SS allow us to establish their exact nature, sometimes only during long-term observation. The aim of the work was to study the state of the joints and bone mineral density in patients with SS and the possibility of correcting these disorders by including amaranth oil in therapy. An experimental study was conducted on 33 white Wistar rats of outbred breeding and clinical observation of 21 patients with Sjogren syndrome. On the model of dexamethasone joint damage in rats, the important pathogenetic role of glucocorticoids in the development of dystrophic-degenerative processes in cartilage and bone tissues was confirmed. The use of amaranth oil in these conditions led to significant positive changes, which was expressed in the inhibition of destructive changes in the bones and cartilage of experimental animals. The defeat of the osteo-articular system in patients with Sjogren’s syndrome was characterized by the presence of arthralgia and morning stiffness. Densitometry revealed a decrease in bone mineral density of the lumbar spine and femoral neck in patients who took glucocorticoids and in patients who did not take glucocorticoids, which can be explained by the negative effect of the inflammatory process on bone structure. The inclusion of amaranth oil in the complex treatment of patients with Sjogren’s syndrome ensured the preservation of bone mineral density due to the inhibition of negative changes in the metabolism of bone and cartilage tissue in patients with lesion of the musculoskeletal system. It can be assumed that this effect is associated with squalene – a natural antioxidant that contained in amaranth oil.

amaranth oil, Sjogren syndrome, dystrophic bone changes.

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«Bulletin of problems biology and medicine» Issue 2 Part 1 (150), 2019 year, 216-220 pages, index UDK 616.7 - 008.6 - 08:615.322

10.29254/2077-4214-2019-2-1-150-216-220