MODERN VIEWS ON THE FUNCTIONAL MORPHOLOGY OF THE MUCOUS MEMBRANE OF THE TONGUE AND ITS CHANGES IN THE CONDITIONS OF SOMATIC DISEASES AND THE INFLUENCE OF INDIVIDUAL EXOGENOUS POLLUTANTS

Koka V. M., Starchenko I. I., Mustafina H. M., Royko N. V

LITERATURE REVIEWS

Scentific article

In the work on the basis of the analysis of modern scientific literary sources the data concerning the structure and functional features of the mucous membrane of the tongue are presented. Links to local immunity, in which the structural components of the mucous membrane of the tongue are involved, are identified. The main pathomorphological changes of the tongue in the conditions of diseases of the internal organs and systems, such as inflammatory diseases of the gastrointestinal tract, diseases of the adrenal glands and thyroid gland, tumors of the blood system are listed. Experimental data on the negative effect on the mucous membrane of the tongue of certain types of dental materials, including those containing amalgam, derivatives of acrylic and methacrylic acids, are presented. Much attention is paid to changes in the tongue that occur under the influence of pathogenic environmental factors such as radiation, excess fluorine, thermal and chemical burns. The necessity of a detailed experimental study of the structural and functional features of the mucous membrane of the tongue under the conditions of isolated and combined exposure of common food additives, the negative effects of which are systematically used experimentally and clinically for individual organs and systems of humans and experimental animals, is substantiated.

mucous membrane of the tongue, exogenous pollutant, nutritional supplements, somatic diseases.

1. Borovskyi EV, Leontev VK. Byolohyia polosty rta. Moskva: Medytsynskaia knyha; 2001. 304 s. [in Russian].
2.  Lamont R, Lantts MS, Berne RA. Mykrobyolohyia y ymunolohyia dlia stomatolohov. Moskva: Praktycheskaia medytsyna; 2010. 504 s. [in Russian].
3. Savichuk NO. Kolonizatsiina rezystentnist slyzovoi obolonky porozhnyny rota – suchasni pidkhody do korektsii. Sovremennaia stomatolohyia. 2011;3:87-91. [in Ukrainian].
4. Hasiuk NV, Boichenko ON, Herasymenko SB. Epytelyotsyti rotovoi polosty kak markeri molekuliarno-henetycheskykh yssledovanyi. Matematycheskaia morfolohyia. Elektronnyi matematycheskyi medyko-byolohycheskyi zhurnal [Internet]. 2013;12(2). Dostupno: http://www. smolensk. ru/user/sgma/MMORPH/N-38-html/ cont. htm [in Russian].
5. Juan Ye. Bacillus as a potential diagnostic marker for yellow tongue coating. Nature [Internet]. 2016;6:32496. Available from: https://www. nature.com/articles/srep32496#article-info
6. Granholm T, Soder O. Constitutive production of lymphocyte activating factors by normal tissues in the adult rat. Cell Biochem. 1991 Jun;46(2):143-51.
7. Van Loon LAJ, Krieg SR, Davidson CL. Quantification and distribution of lymphocytes subsets and Langerhans cells in normal human oral mucosa and skin. J. Oral Pathol. 1989;18:197-201.
8. Pitigala-Arachchi A, Crane IJ, Scully C. Epithelial dendritic cells in pathological human oral tissues. J. Oral Pathol. Med. 1989;18:11-6.
9. Shyrokobokov VP. Medychna mikrobiolohiia, virusolohiia ta imunolohiia. Vinnytsia: Nova Knyha; 2011. 890 s. [in Ukrainian].
10. Tymchuk IV, Panas MA, Leshchuk SYe. Vplyv lizotsymu i slyny na adheziini vlastyvosti C. albicans, vydilenykh z rotovoi porozhnyny v doslidakh in vitro. Acta medica Leopoliensia. 2014;3-4(20):45-50. [in Ukrainian].
11. Brognen KM, Guthmiller JM. Polymicrobial diseases. Washington: ASM Press; 2008. 328 p.
12. Metwalli KH, Khan SA, Krom BP, Jabra-Rizk MA. Streptococcus mutans, Candida albicans, and the Human Mouth: A Sticky Situation. PLoS Pathogiu [Internet]. 2013;9(10). Available from: http://www. e1003616.doi:10.1371/journal.ppat.1003616
13. Hemonov VV, Lavrova EN, Falyn LY. Atlas po hystolohyy y embryolohyy orhanov rotovoi polosty y zubov. Moskva: 2003. 96 s. [in Russian].
14. Gartner LP, Hiatt JL. Color Atlas of Histology. Baltimore: 2000. 444 p.
15. Panasiuk YeM, Zaiachkivska OS. Yazyk: klinichni ta fiziolohichni osnovy linhvodiahnostyky. Lviv: Svit; 2000. 56 s. [in Ukrainian].
16. Babyi YL, Kalashnykova EA. Allerhycheskye porazhenyia y yzmenenyia slyzystoi obolochky polosty rta pry razlychnykh zabolevanyiakh orhanov y system u detei. Zdorove rebenka. 2010;2(23):97-9. [in Russian].
17. Kaptsov VA, Chyrkyn AV. Ob effektyvnosty sredstv yndyvydualnoi zashchyty orhanov dykhanyia kak sredstva profylaktyky zabolevanyi (obzor). FBUZ «Rossyiskyi rehystr potentsyalno opasnykh khymycheskykh y byolohycheskykh veshchestv» Rospotrebnadzora Toksykolohycheskyi vestnyk. 2018;2(149):2-6. [in Russian].
18. Zykova OS. Porazhenye slyzystoi obolochky polosty rta y krasnoi kaimу hub pry psoryaze Dermatovenerolohyia. Kosmetolohyia [Internet]. 2015;4:59-65. Dostupno: https://rucont.ru/efd/478871 [in Russian].
19. Aasebo U, Kjaer KG. Lead poisoning as possible cause of deaths at the Swedish House at Kapp Thordsen, Spitsbergen. London: BMJ Group; 2009.
20. Davydenko V, Starchenko I, Trufanova V, Kuznetsov V. The impact of the acrylic monomer on the morphological structure of rat lingual mucosa. Georgian Med News. 2018;278:146-51.
21. Davydenko V, Nidzelskiy M, Starchenko I, Davydenko A, Kuznetsov V. Morphological features of rat mucous membrane of the tongue early affected by acrylic resin monomer. Georgian Med News. 2016 Mar;252:102-7.
22. Tobacman JK. Review of harmful gastrointestinal effects of carrageenan in animal experiment. Environ Health Perspect [Internet]. 2001 Oct;109(10):983-94. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1242073/
23. Ocenka nekotoryh pischevyh dobavok i kontaminantov: sorok devyatyy doklad Ob’edinennogo komiteta ekspertov FAO/VOZ po pischevym dobavkam. Vsemirnaya organizaciya zdravoohraneniya [Internet]. Zheneva: Shveycariya; ‎1999. [obnovleno 2013-09-25T10:57:20Z;]. Dostupno: https://apps.who.int/iris/handle/10665/89207 [in Russian].
24. Di Lorenzo G, Martinelli N, Mansueto P, Rini GB. Monosodium benzoate hypersensitivity in subjects with persistent rhinitis. Allergy [Internet]. 2004 Feb;59(2):192-7. Available from: https://www.ncbi.nlm.nih.gov/pubmed/14763933

«Bulletin of problems biology and medicine» Issue 3 (152), 2019 year, 27-30 pages, index UDK 616.311/.313:615.24

10.29254/2077-4214-2019-3-152-27-30