Bahmut I. Yu., Pohoryelov V. V., Zhukov V. I.

COMPRESSION DESTRUCTIVE DAMAGES OF THE SPINAL ROOTS AND ASPECTS OF ANTIOXIDANT PROTECTION OF NEUROVASCULAR STRUCTURES OF LUMBAR SPINE


About the author:

Bahmut I. Yu., Pohoryelov V. V., Zhukov V. I.

Heading:

CLINICAL AND EXPERIMENTAL MEDICINE

Type of article:

Scentific article

Annotation:

Compression injury of lumbar spinal roots is a disease that basically has neurodestructive changes that occur as a result of metabolic changes in homeostasis, as a response to oxidative stress. In this regard, we investigated the effect of immune inflammation on lipid oxidation and antioxidant protection of glutathione and revealed their interrelationships. 76 patients with chronic compression of spinal roots took part in the investigation, divided into two groups. The group of control consisted of 30 healthy people. Patients of the first group took complex therapy including pentoxifylline. Patients of the second group (45 patients) additionally to this therapy were treated by melatonin C-3. There were investigated rates of immune inflammation – interleukins: -1β, -6 and tumor necrosis factor-α, lipid peroxidation – malonic dialdehyde, state of antioxidant protection – catalase, ceruloplasmine, oxidized and reduced glutathione, glutathione peroxidase. Also studied indicators of blood lipid spectrum – total cholesterol, low-density lipoproteins and high-density lipoproteins, rates of serotonin. As a result of the treatment were reliable increase of enzymes of antioxidant protection, decrease of rates of immune inflammation, lipid peroxidation. The most pronounced these changes were in the second group in which used combination of pentoxifylline + melatonin. Thus, the use of melatonin with the pentoxifylline in the complex therapy of compression radiculopathy contributes to the inhibition of neurodegeneration and leads to a more rapid recovery of nerve roots and is pathogenetically substantiated.

Tags:

glutathione antioxidant protection, compression neurodestruction, pentoxifylline + melatonin.

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Publication of the article:

«Bulletin of problems biology and medicine» Issue 3 (152), 2019 year, 66-69 pages, index UDK 616.833.2-005.4-008.9-092-07-085.21+615.27

DOI: