FEATURES OF CREATININ CLEARANCE CHANGE IN ISCHEMIC HEART DISEASE COMPLIED BY OBESITY

Lapovets L. Ye., Bashta H. V., Shchurko M. M., Tkachuk S. O.

CLINICAL AND EXPERIMENTAL MEDICINE

Scentific article

Mortality from coronary heart disease is about 650 per 100 thousand population (Kovalenko VM, Dorogoy AP, 2016). In developed countries, coronary heart disease is the most common cardiovascular disease, and myocardial infarction is the most common cause of death. Men are more likely to become ill, especially at the age of 40-55 years. The morbidity, mortality, and socioeconomic importance of widespread pathology such as coronary heart disease (CHD) make research extremely important in order to accurately diagnose, prevent, and prevent the development of the disease. The article presented correlates of creatinine clearance and metabolic rate in patients with coronary artery disease with and without obesity. For the study, 30 patients with verified coronary heart disease were taken, including 20 patients with non-obesity coronary heart disease (15 men, 5 women) and 10 patients with obesity (9 men, 1 woman). The mean age of the patients was 55 ± 2 years. The diagnosis of obesity was given by body mass index. Control group – 20 practically healthy persons of age and sex. Because, in obesity, not only excess fat is characteristic, but also a complex complex of metabolic disorders. The presence of metabolic disorders can be assessed by many laboratory data, especially glucose, triacylglycerols and other indicators. Plasma glucose content in patients with coronary heart disease exceeds normal by 76% (p <0.05), in patients with coronary artery disease complicated by obesity, glucose content exceeds the control by 56% (p <0.05). There was also a significant difference (p <0.05) between the groups of patients. The content of total cholesterol (CHC) in the blood plasma of patients with coronary heart disease exceeds the norm by 10% (p <0.05), in patients with coronary artery disease complicated by obesity, glucose content exceeds the control by 17% (p <0.05). There was also a significant difference (p <0.05) between the groups of patients. The content of triacylglycerol in the blood plasma of patients with coronary heart disease exceeds the norm by 12% (p <0.05), in patients with coronary artery disease complicated by obesity, the glucose content exceeds the control by 37% (p <0.05). There was also a significant difference (p <0.05) between the groups of patients. LDL-cholesterol content in blood plasma of patients with coronary heart disease exceeds the norm by 0.9% (p <0.05), in patients with coronary artery disease complicated by obesity, glucose content exceeds the control by 2% (p <0.05). There was also a significant difference (p <0.05) between the groups of patients.In the cohort of patients with coronary artery disease, obesity lesions with normal glomerular filtration were found in 50%, and chronic renal failure with moderately reduced glomerular filtration in 20% of patients. In the coronary artery disease group, obesity revealed renal lesions with normal glomerular filtration in 39%, chronic renal insufficiency with moderately reduced glomerular filtration in 23% of patients, and chronic renal failure with moderate reduced glomerular filtration. The analysis of creatinine clearance indicators revealed more frequent manifestations of chronic renal failure with reduced glomerular filtration in coronary artery disease complicated by obesity. Creatinine clearance correlates positively with red blood counts, negatively with patients’ age. No significant correlation was found with lipid, carbohydrate metabolism. In obesity, correlative links with red blood counts disappear, which may indicate dysregulation in the metabolic syndrome

coronary heart disease, obesity, glucose, lipids, creatinine clearance.

1. Kovalenko VM, Dorohoy AP. Sertsevo-sudynni khvoroby: medychno-sotsialʹne znachennya ta stratehiya rozvytku kardiolohiyi v Ukrayini. Ukrayinsʹkyy kardiolohichnyy zhurnal. 2016;4(3):5. [in Ukrainian].
2. Dzyak HV, Khomazyuk TA. Podahra: «kapkan» metabolichnykh problem. Dnipropetrovsʹk: OOO «Royal Prynt»; 2010. s. 112. [in Ukrainian].
3. Scott D Mendelson, MD, PhD. Metabolic Syndrome and Psychiatric Illness: Interactions, Pathophysiology, Assessment and Treatment. Nabu Press, I. Latin Edition December 19, 2007. p. 68.
4. Goryachkovskiy AM. Klinicheskaya biokhimiya v laboratornoy diagnostike. Odessa: Ekologiya; 2005. s. 616. [in Russian].
5. Jan Tatoń, Anna Czech, Małgorzata Bernas. Otyłość. Zespół metaboliczny. Wydawca: Wydawnictwo Lekarskie; 2016. p. 130.
6. Farzaneh Montazerifar, Ahmad Bolouri, Milad Mahmoudi Mozaffar, Mansour Karajibanid. The Prevalence of Metabolic Syndrome in Coronary Artery Disease Patients. Cardiol Res. 2016 Dec;7(6):202-8.

«Bulletin of problems biology and medicine» Issue 3 (152), 2019 year, 143-146 pages, index UDK 616-005.4-06:616-056.52:547.495.9]-07

10.29254/2077-4214-2019-3-152-143-146