MICROSCOPIC CHANGES IN THE STRUCTURAL COMPONENTS OF RATS PERIODONTIUM IN CASE OF PERIODONTITIS ON THE BACKGROUND OF HYPOTHYROIDISM

Shcherba V. V., Machogan V. R., Nebesna Z. M., Korda M. M.

MORPHOLOGY

Scentific article

Periodontal diseases rank second in the world in dental diseases prevalence and tend to be widespread, regardless of patients’ age, gender, and place of residence. The rate of destruction of periodontal tissues in case of periodontitis depends on different factors, including anatomical and physiological features of the periodontium.The aim of our study was to investigate the structural changes of periodontal tissues in experimental periodontitis on the background of hypothyroidism. The study was conducted on 36 white male rats, which were divided into the following groups: I – control animals; ІІ – animals with the model of periodontitis; III – rats with periodontitis and hypothyroidism. Periodontal tissues were subjected to histological examination on the 22nd day of the study. In experimental periodontitis, reorganization of all structural components of the periodontium was established, which was manifested by changes in the epithelium of the mucous membrane of the gums, both free and areas of the furrow and attachment. An increase in the stratum corneum of the epithelium and a thickening of the prickly one were found. In the connective tissue of the gum, the signs of collagen degradation are determined against the background of disorganization. The reaction of the vascular bed was manifested by enlargement, hemorrhage of the veins and hemocapillaries, and narrowing of the lumens and thickening of the artery wall, which probably worsens the trophic cells of the epithelial plate, the connective tissue of the mucous membrane and is manifested by amphoric swelling. In case of periodontitis on the background of hypothyroidism destructive and necrotic changes of the epithelial and own plaque of the gums, periodontium, blood vessels, alveolar process and cement of the root of the tooth are established, which testifies to the suppression of the adaptive-compensatory and reparative processes and have irreversible processes.

periodontitis, hypothyroidism, periodontium, structural changes

1. Pavlenkova E, Pavlenko S, Tkachenko I, Sidorova A. Kliniko-laboratornoe obosnovanie ispolzovaniia preparata na osnove antiseptika Troklosene dlia lecheniia patcientov s khronicheskim generalizovannym parodontitom ІІ i ІІІ stepeni tiazhesti. Wiad Lek. 2018;71(4):855-60. [in Russian].
2. Tomilina TV. Razvitie disbioza v parodonte krys posle splenektomii. Journal of Health Sciences. 2014;04(01):125-34. [in Russian].
3. Shcherba VV, Korda MM. Osoblyvosti mikrobiotsenozu rotovoi porozhnyny u shchuriv iz parodontytom na tli hiper- ta hipotyreozu. Klinichna stomatolohiia. 2019;2:65-71. [in Ukrainian].
4. Shnaider SA. Morfohenez eksperymentalnoho khronichnoho parodontytu. Morfolohiia. 2011;1:38-41. [in Ukrainian].
5. Moiseeva EG. Metabolicheskii gomeostaz i imunnaia reaktivnost organizma v dinamike vospaleniia v tkaniakh parodonta (eksperimentalnoe issledovanie) [avtoreferat]. Moskva: Rossiiskii Universitet druzhby narodov; 2008. 45 s. [in Russian].
6. Ratushnenko VO. Funktsionalna rol tiol-dysulfidnoi systemy pry eksperymentalnomu hipo- i hipertyreozi. Odeskyi medychnyi zhurnal. 2010;2(118):17-20. [in Ukrainian].
7. European convention for the protection of vertebrate animals used for experimental and other scientific purposes. Council of Europe. Strasbourg. 1986;123:52.
8. Horalskyi LP, Khomych VT, Kononskyi OI. Osnovy histolohichnoi tekhniky i morfofunktsionalni metody doslidzhen u normi ta pry patolohii. Zhytomyr: Polissia; 2011. 288 s. [in Ukrainian].
9. Bilash SM, Pronina OM, Koptev MM. Comprehensive morphological studies as an intergal part of modern medical science. Literature review. Visnyk problem biolohiyi i medytsyny. 2019;2.2(151):20-3. DOI: 10.29254/2077-4214-2019-2-2-151-20-23
10. Shcherba VV, Korda MM. Rol dysfunktsii shchytopodibnoi zalozy u patohenezi heneralizovanoho parodontytu (ohliad literatury). Klinichna stomatolohiia. 2018;1:60-71. [in Ukrainian].
11. Oganyan AV. Kliniko-morfologicheskie izmeneniya zubo-chelyustnoy sistemy pri gipotireoze. Extended abstract of Doc¬tor’s thesis. Stavropol; 2010. 22. [in Russian].

«Bulletin of problems biology and medicine» Issue 3 (152), 2019 year, 314-319 pages, index UDK 616.314.17-008.1-091.8-06:616.441-008.64]-092.9

10.29254/2077-4214-2019-3-152-314-319