EFFECT OF COURSE APPLICATION OF QUERCETIN ON RESISTANCE TO HYPOXIA IN ELDERLY PEOPLE WITH METABOLIC SYNDROME

Korkushko O. V., Shatilo V. B., Antoniuk-Shcheglova I. A., Bondarenko O. V., Naskalova S. S., Gavalko A. V., Grib O. M.

CLINICAL AND EXPERIMENTAL MEDICINE

Scentific article

The search for safe and effective drugs that can influence the course and correction of metabolic syndrome, especially in the older age group, has drawn attention to the possibilities of using an antioxidant from the bioflavonoid group, quercetin. The search for literature data indicates the absence of clinical studies on the use of quercetin in order to increase resistance to hypoxia in elderly people with metabolic syndrome. The aim of the study. To establish the response to an acute hypoxic test in the elderly people with metabolic syndrome after a course of quercetin in comparison with the control group. The object was 110 elderly patients with metabolic syndrome criteria, of which 55 people took quercetin (drug “Kvertin” PAO SPC «Borshchahivskiy CPP», 80 mg three times a day for 3 months), and 55 people took placebo and formed a control group. Methods. Anthropometric measurements; biochemical study with determination of glucose in blood plasma, lipids in blood serum; measurement of blood pressure; hypoxic test to determine resistance to hypoxia. Results. The course use of quercetin led to a less significant decrease in SрO2 in the main group of patients during the hypoxic test. Also, in the main group, after treatment, there was a statistically significant decrease in systolic and diastolic blood pressure, both at the beginning of HP and at 20 minutes of HP compared to the baseline level and the control group. In addition, there was a statistically significant decrease in the double product – an indicator that indirectly characterizes the level of oxygen consumption by the myocardium in the main group compared to the control group. Conclusions. Course use of quercetin significantly increases the body’s resistance to hypoxia in elderly patients with metabolic syndrome. The antihypoxic effect of quercetin can be used to correct conditions associated with oxygen deficiency.

elderly people, quercetin, metabolic syndrome, hypoxia.

1. Saklayen MG. The Global Epidemic of the Metabolic Syndrome. Curr Hypertens Rep. 2018;20(2):12.
2. Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, et al. Harmonizing the metabolic syndrome: a joint interim statement of the international diabetes federation task force on epidemiology and prevention. Circulation. 2009;120(16):1640-5.
3. Roberts CK, Sindhu KK. Oxidative stress and metabolic syndrome. Life Sciences. 2009 May;84(21-22):705-12.
4. Furukawa S, Fujita T, Shimabukuro M. Increased oxidative stress in obesity and its impact on metabolic syndrome. J. Clin. Investig. 2004;114:1752-61.
5. Formica JV, Regelson W. Review of the Biology of Quercetin and Related Bioflavonoids: A literature review. Fd Chem. Toxic. 1995;33(12):1061-80.
6. Granado-Serrano AB, Martín MA, Bravo L, Goya L, Ramos S. Quercetin modulates Nrf2 and glutathione-related defenses in HepG2 cells: Involvement of p38. Chem Biol Interact. 2012 Jan 25;195(2):154-64.
7. Askari G, Ghiasvand R, Feizi A, Ghanadian SM, Karimian J. The effect of quercetin supplementation on selected markers of inflammation and oxidative stress. J Res Med Sci. 2012;17:637-41.
8. Ademosun AO, Oboh G, Bello F, Ayeni PO. Antioxidative Properties and Effect of Quercetin and Its Glycosylated Form (Rutin) on Acetylcholinesterase and Butyrylcholinesterase Activities. J. Evid. Based omplement. Altern. Med. 2016;21:11-7.
9. Kobori M, Takahashi Y, Akimoto Y, Sakurai M, Matsunaga I, Nishimuro H, et al. Chronic high intake of quercetin reduces oxidative stress and induces expression of the antioxidant enzymes in the liver and visceral adipose tissues in mice. J. Funct. Foods. 2015;15:551-60.
10. García-Mediavilla V, Crespo I, Collado PS, Esteller A, Sánchez-Campos S, Tuñón MJ, et al. The anti-inflammatory flavones quercetin and kaempferol cause inhibition of inducible nitric oxide synthase, cyclooxygenase-2 and reactive C-protein, and down-regulation of the nuclear factor kappaB pathway in Chang Liver cells. Eur J Pharmacol. 2007;557:221-9.
11. Adedara IA, Ego VC, Subair TI, Oyediran O, Farombi EO. Quercetin Improves Neurobehavioral Performance through Restoration of Brain Antioxidant Status and Acetylcholinesterase Activity in Manganese-Treated Rats. Neurochem. Res. 2017;42:1219-29.

«Bulletin of problems biology and medicine» Issue 4 (158), 2020 year, 156-160 pages, index UDK 616-098:616-092:615.2

10.29254/2077-4214-2020-4-158-156-160