Kaskova L. F., Kulay O. A., Andriyanova O. Yu., Babanina S. M., Khmil E. V., Danilenko V. V., Tovma V. V.

THE MEDICAL DRUG INCLUDING HYALURONIC ACID WAS USED FOR THE TREATMENT OF SYMPTOMATIC GINGIVITIS IN CHILDREN WITH ACUTE HERPETIC STOMATITIS


About the author:

Kaskova L. F., Kulay O. A., Andriyanova O. Yu., Babanina S. M., Khmil E. V., Danilenko V. V., Tovma V. V.

Heading:

DENTISTRY

Type of article:

Scentific article

Annotation:

The medical drugs with an anti-inflammatory and healing features widely applied for the complex therapy of an acute herpetic stomatitis and periodontal diseases in children. The special periodontist attention deal with medical drug included hyaluronic acid. The main purpose of our researches were determined the clinical efficiency of medical drug with the sodium hyaluronic 0,2% and estimation of its influence on the periodontal tissues in the complex therapy of acute herpetic stomatitis in children. The 44 children were examined a treated with acute herpetic stomatitis with light and severity forms in the municipal children clinical dental polyclinic town Poltava. There were 21 boys and 23 girls aged till 1 to 3 years. The acute catarrhal gingivitis (ACG) was a diagnosed in the entire patient with an acute herpetic stomatitis (AHS). There were 20 children with light degree of ACG and 24 children with its middle degree. Clinical signs of the pathological process extinction during a treatment of gingivitis were appeared on 3.83 ± 0.24 days, signs of the pathological process disappearance in the gums were determined on 6.85 ± 0.22 days. The treatment effectiveness was confirmed by the dynamics of paraclinical methods. Significantly, the PMA and GI indices were decreased after 3-5 days. Thus, the PMA index was 23,87 ± 2,84% (р˃0,05) before treatment in the group used sodium hyaluronate and after treatment was 4.61 ± 0.92% (p˂0.05). GI was 0.928 ± 0.024 scores (р˃0,05) before treatment in this group and after treatment, respectively, was 0,62 ± 0,020 scores (p˂0,05). The sodium hyaluronic stipulated positive effect on the inflammatory process in periodontal tissues and reduce the treatment period. The treatment efficiency stipulated with high molecular weight of the hyaluronic acid who was conditioned the elasticity, stability and protective functions of the connective tissue, the swelling and inflammation discontinue and promoted the fast regeneration of periodontal tissues.

Tags:

periodontitis, inflammation, sodium hyaluronate, acute herpetic stomatitis

Bibliography:

  1. Vinogradova TF, Maksimenko OP, Mel’nichenko EM. Zabolevaniya parodonta i slizistoy obolochki polosti rta u detey. Meditsina; 1983. 208 s. [in Russian].
  2. Savichuk NO. Immunomodulyator bakterial’nogo proiskhozhdeniya imudon v lechenii assotsiirovannoy formy khronicheskoy kandidogerpeticheskoy infektsii slizistoy obolochki polosti rta i gub u detey. Sovremennaya stomatologiya. 2000;1:51-4. [in Russian].
  3. Baranayeva AYe, Merkulova YeP. Ostryy gerpeticheskiy stomatit u detey. Klinicheskaya praktika i zdorov’ye. 2013;1:35-6. [in Russian].
  4. Kasʹkova LF, Karpenko OO, Khmilʹ OV. Klitynnyy imunitet pry herpesvirusniy infektsiyi slyzovoyi obolonky porozhnyny rota u pidlitkiv z endokrynnoyu patolohiyeyu. Innovatsiyni tekhnolohiyi v stomatolohiyi ta klinichniy medytsyni: materialy mizhnarodnoyi naukovopraktychnoyi konferentsiyi prysvyachenoyi 90-richchyu VDNZU «Ukrayinsʹka medychna stomatolohichna akademiya» (6-7 zhovtnya 2011 r.) Poltava. 2011. Problemy ekolohiyi ta medytsyny. 2011;3-4 (dodatok):90. [in Ukrainian].
  5. Kasʹkova LF, Khmilʹ OV, Sirkovych IO. Herpetychna infektsiya v dytyachiy stomatolohiyi. Navchalʹnyy posibnyk. Poltava; 2011. 120 s. [in Ukrainian]. 
  6. Levonchuk YeA. Gerpeticheskaya infektsiya polosti rta. Sovremennaya stomatologiya. 2005;1:19-23. [in Russian].
  7. Khmilʹ OV. Hostryy herpetychnyy stomatyt. Lektsiya. Aktualʹni problemy suchasnoyi medytsyny. 2017;4:244-8. [in Ukrainian].
  8. Suga S, Asano Y. Clinical manifestations of the subfamily alpha-herpesvirinae in childhood. Nippon Rinsho. 2000;4(58):890-4.
  9. Khmilʹ OV, Karpenko OO, Kolot EH. Vykorystannya «Kahotselu» v likuvanni ditey iz virusnymy zakhvoryuvannyamy slyzovoyi obolonky porozhnyny rota. Suchasni pytannya ortodontiyi. Mistse ortodontiyi sered stomatolohichnykh spetsialʹnostey: materialy naukovo-praktychnoyi konferentsiyi z mizhnarodnoyu uchastyu (12-13 kvitnya 2012r.). Ukrayinsʹkyy stomatolohichnyy alʹmanakh. 2012;2(1):109. [in Ukrainian].
  10. Hoglund M, Ljungman P, Weller S. Comparable aciclovir exposures produced by oral valaciclovir and intravenous aciclovir in immunocompromised cancer patients. J Antimicrob Chemother. 2001;6(47):855-61.
  11. Bryant P, Sasadeusz J, Carapetis J, Waters K, Curtis N. Successful treatment of foscarnet-resistant herpes simplex stomatitis with intravenous cidofovir in a child. Pediatr Infect Dis J. 2001;11(2)11:1083-6.
  12. Kuz’mina EM. Profilaktika stomatologicheskikh zabolevaniy. Uchebnoye posobiye. Iz-vo: «Tonga-Print»; 2001. 216 s. [in Russian].
  13. Zyuzin VO. Statystychni metody v okhoroni zdorovʺya ta medytsyni. Poltava: UMSA; 1995.112 s. [in Ukrainian].

Publication of the article:

«Bulletin of problems biology and medicine» Issue 4 Part 2 (147), 2018 year, 334-336 pages, index UDK 616.311.2-002-06:616.31-002-022.7:578.825)-085:615.262-053.2

DOI: