DETERMINANTS OF FORMING CHARACTERISTICS OF A GROUP OF HYPERTENSIVE PATIENTS WITH VARIOUS BODY WEIGHT AND TYPE 2 DIABETES MELLITUS

Psarova V. G.

CLINICAL AND EXPERIMENTAL MEDICINE

Scentific article

The purpose of the work was to assess the factors that are fundamental in the formation of a group of hypertensive patients with different body mass and type 2 diabetes mellitus. 340 patients with AH aged 45 to 55 who gave informed written consent to participate in the study and met the inclusion criteria were examined. Group 1 consisted of 200 patients with AH and obesity I–II classes, group 2 – 50 patients with AH and normal body weight, group 3 – 50 patients with AH and overweight, 4 group – 40 patients with AH, obesity I–II classes and type 2 diabetes mellitus. Analysis included 64 indicators. In the factor analysis of the group of hypertensive patients 4 factors were found. Those factors explained 24,86% of the variability of the indicators. The data of the logistic regression method showed that the formation of a group of hypertensive patients with different body weight and type 2 diabetes mellitus was influenced by anthropometric indicators (BMI (р = = 0,0045)), metabolic indicators (HOMA index (р = 0,0040), adiponectin (р = 0, 0117), glycosylated hemoglobin (p = 0.0411)), hemodynamic parameters (mean BP (p = 0.0182)), RAAS activity (aldosterone (р = 0,0067)), antioxidant defense system performance (general antioxidant protection (р = 0,0489)), systolic (of course the systolic diameter of the left ventricle (р = 0,0044)) and diastolic cardiac function (MV A (р = 0,0381)), as well as ADIPOQ genetic polymorphism (р = 0,0073).

hypertension, obesity, diabetes mellitus, factor analysis, logistic regression.

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«Bulletin of problems biology and medicine» Issue 4 Part 2 (154), 2019 year, 188-192 pages, index UDK 616.12-008.33:[616.379-008.64+613.25]

10.29254/2077-4214-2019-4-2-154-188-192