Mirzebasov M. A.


About the author:

Mirzebasov M. A.



Type of article:

Scentific article


Diseases of the digestive system in the modern world remain one of the serious problems. It is known that the state of the digestive system is largely dependent on the environment. The influence of anthropogenic pollutants can lead to the development of disorders of the digestive system. One of the most widespread pollutants is epichlorohydrin (ECH). This chemical can negatively affect human health. However, the regularities of the effects of ECH on the state of the duodenum have not been studied enough. There is also insufficient scientific data on the experimental justification of methods for preventing the development of disorders arising in duodenum due to the negative effects of ECH, and methods for correcting these disorders. The aim of the study was to assess the state of the columnar epithelial cells of the villi of the mucous membrane (MM), duodenum in terms of the long-acting ECH in rats, and determine the feasibility of application of an extract of Echinacea purpurea (EP) and thiotriazoline for the correction of occurring disorders. Under the influence of ECH, changes occurred in the nucleus and cytoplasm of columnar epithelial cells of villi of duodenum MM. Compared with the corresponding indicators of the control group rats, the cut-off area (Sca) of the nucleus and the Ph of the cytoplasm of these cells decreased, and the nuclear-cytoplasmic index (NCI) increased. The use of EP extract on the background of the introduction of ECH reduced the timing of reduction of Sca of the nucleus of columnar epithelial cells of villi caused by the action of ECH. The use of thiotriazoline during inhalation significantly reduced the time to reduce the Sca of the nucleus and the Sca of the cytoplasm of columnar epithelial cells of the villi. These facts indicate the expediency of using EP extract and thiotriazoline as correctors of duodenum MM disorders induced by ECH.


duodenum, columnar epithelial cells, epichlorohydrin, rats


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Publication of the article:

«Bulletin of problems biology and medicine» Issue 4 Part 2 (154), 2019 year, 308-311 pages, index UDK 616.342 :546-3